{"id":"W4399535331","doi":"10.1038/s41467-024-49211-2","title":"Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Spaceflight effects on biology","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"National Institute of Mental Health; National Cancer Institute; National Institutes of Health; National Research Foundation of Korea; Nuclear Safety and Security Commission; National Research Foundation; National Institute of Allergy and Infectious Diseases; WorldQuant Foundation; Stop Cancer; National Aeronautics and Space Administration","keywords":"Spaceflight; Crew; Immune system; Biology; Cell; Cell type; Human spaceflight; Computational biology; Genetics; Aeronautics; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000405439,0.0001733675,0.0002895337,0.0001937362,0.0002048371,0.0000445976,0.0003765497,0.0003275002,0.00001477851],"category_scores_gemma":[0.0004123656,0.0001202193,0.00005388758,0.0006928551,0.0003975552,0.00006062856,0.000453579,0.0008258022,0.0000140574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005057585,"about_ca_system_score_gemma":0.0001452751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002698345,"about_ca_topic_score_gemma":0.0000974089,"domain_scores_codex":[0.9987473,0.0003813519,0.0002943616,0.0002759737,0.0001379058,0.0001630936],"domain_scores_gemma":[0.9969543,0.00106418,0.00008793027,0.001566204,0.0002339448,0.00009348848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001614121,0.000291784,0.02080276,0.0002295068,0.00005307365,0.000005470678,0.001269721,3.749358e-7,0.964677,0.002508655,0.008888812,0.001111418],"study_design_scores_gemma":[0.001477288,0.0007519769,0.1480223,0.0005966127,0.0001709215,0.0001469253,0.0005228042,0.0002220443,0.3465855,0.00006770311,0.5011148,0.0003210497],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8069966,0.1550561,0.00002705025,0.03292574,0.0003079262,0.001366933,0.00006714568,0.0001153776,0.003137089],"genre_scores_gemma":[0.9834033,0.001575327,0.01027569,0.0006761679,0.00004145658,0.00004567432,0.00004253639,0.00002944592,0.003910406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6180915,"threshold_uncertainty_score":0.4902401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03875103400287583,"score_gpt":0.3134866585230991,"score_spread":0.2747356245202233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}