{"id":"W4399538921","doi":"10.1007/s00401-024-02749-3","title":"Early and selective localization of tau filaments to glutamatergic subcellular domains within the human anterodorsal thalamus","year":2024,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; Reta Lila Weston Institute of Neurological Studies, UCL Queen Square Institute of Neurology,University College London; Nemzeti Kutatási, Fejlesztési és Innovaciós Alap; NIHR Oxford Biomedical Research Centre; Universitätsspital Zürich; Medical Research Council; John Fell Fund, University of Oxford; National Institute for Health and Care Research; Alzheimer Society; Wellcome Trust","keywords":"Glutamatergic; Biology; Thalamus; Neuroscience; Neurodegeneration; Axon; Axon terminal; Population; Cell biology; Glutamate receptor; Pathology; Disease; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004700388,0.0002148731,0.0002087499,0.0002088374,0.0004351473,0.0001787156,0.0005969831,0.00006160776,0.00002098598],"category_scores_gemma":[0.0004714105,0.0001383522,0.00005542774,0.001012734,0.0006494262,0.0002398205,0.0004172199,0.0004198859,0.00003703385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001733454,"about_ca_system_score_gemma":0.00003351688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006775567,"about_ca_topic_score_gemma":7.874562e-7,"domain_scores_codex":[0.9970719,0.0009147117,0.0003071098,0.0008654905,0.000426926,0.0004138346],"domain_scores_gemma":[0.9990475,0.0003873599,0.00008583177,0.0003151302,0.00004094861,0.0001232864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004613686,0.00006633065,0.002332983,0.00002216381,0.00000184932,0.001298016,0.0007462568,0.000036118,0.9947096,0.0004721171,0.0001681075,0.0001002864],"study_design_scores_gemma":[0.0001964653,0.001240531,0.02353467,0.00002409499,0.00001735324,0.0003797439,0.00002127777,0.0009352467,0.9727054,0.0004310742,0.0003659455,0.0001482631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978375,0.00003021362,0.00009593164,0.0005596605,0.0004474838,0.0005543059,0.00002323972,0.0001387745,0.0003129095],"genre_scores_gemma":[0.9976615,0.00007121424,0.000006766279,0.001804129,0.00004530181,0.00003574837,5.71151e-7,0.00003103055,0.0003437549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0220043,"threshold_uncertainty_score":0.564184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0368970385228313,"score_gpt":0.3203790200965216,"score_spread":0.2834819815736903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}