{"id":"W4399546207","doi":"10.1161/circresaha.123.324202","title":"TRIM35 Monoubiquitinates H2B in Cardiac Cells, Implications for Heart Failure","year":2024,"lang":"en","type":"article","venue":"Circulation Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Health Economics; Northern Alberta Institute of Technology; University of Alberta","funders":"","keywords":"Biology; Gene knockdown; Chromatin immunoprecipitation; Dilated cardiomyopathy; Transcription factor; Chromatin remodeling; Genetically modified mouse; Chromatin; Promoter; Epigenetics; Cell biology; Small interfering RNA; Transgene; Transcriptional regulation; Molecular biology; Histone H2B; Heart failure; Cardiomyopathy; Ubiquitin; RNA; Gene; Gene expression; Internal medicine; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001149502,0.00009017139,0.0001684013,0.0004994693,0.0002014985,0.00008050966,0.000148039,0.0001902595,0.0002450548],"category_scores_gemma":[0.0001798512,0.00008635659,0.0001194793,0.0004345725,0.0001278628,0.0001118749,0.00004898755,0.0003811528,0.0007533731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001203631,"about_ca_system_score_gemma":0.000189287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000102028,"about_ca_topic_score_gemma":0.00002036054,"domain_scores_codex":[0.9985979,0.0004252396,0.0002286211,0.0002999834,0.00003995357,0.0004082695],"domain_scores_gemma":[0.9986006,0.0009351399,0.00001303379,0.0002456484,0.0001874636,0.00001808441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007729982,0.00004576372,0.002125473,0.00006538243,0.00004487678,4.126527e-7,0.0003215222,0.00003326119,0.9369662,0.01056938,0.04622679,0.003523652],"study_design_scores_gemma":[0.0006484173,0.0001753722,0.08346779,0.0001253657,0.0000133249,0.00001257244,0.0007290849,0.0002692855,0.315729,0.002822595,0.5957935,0.0002137329],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658259,0.0156247,0.0008397445,0.01337784,0.0008557735,0.001526046,0.0001666273,0.0001701655,0.001613159],"genre_scores_gemma":[0.9959385,0.00006060517,0.00004794209,0.00003452435,0.0000429651,0.0003372112,0.0001675466,0.00002016592,0.003350576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6212372,"threshold_uncertainty_score":0.9683339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0646308866844324,"score_gpt":0.3874754253953273,"score_spread":0.3228445387108949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}