{"id":"W4399546207","doi":"10.1161/circresaha.123.324202","title":"TRIM35 Monoubiquitinates H2B in Cardiac Cells, Implications for Heart Failure","year":2024,"lang":"en","type":"article","venue":"Circulation Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Health Economics; Northern Alberta Institute of Technology; University of Alberta","funders":"","keywords":"Biology; Gene knockdown; Chromatin immunoprecipitation; Dilated cardiomyopathy; Transcription factor; Chromatin remodeling; Genetically modified mouse; Chromatin; Promoter; Epigenetics; Cell biology; Small interfering RNA; Transgene; Transcriptional regulation; Molecular biology; Histone H2B; Heart failure; Cardiomyopathy; Ubiquitin; RNA; Gene; Gene expression; Internal medicine; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002601666,0.0002093506,0.0001199756,0.0002446859,0.0001605907,0.0002156827,0.0002292292,0.0003486204,0.001333539],"category_scores_gemma":[0.000145499,0.00008532087,0.0001714224,0.00009961834,0.0002277363,0.0001959643,0.0001737483,0.0003758999,0.0003630498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003970229,"about_ca_system_score_gemma":0.0001056181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003755431,"about_ca_topic_score_gemma":0.0006330074,"domain_scores_codex":[0.9999243,0.000009187163,0.000007217905,0.00002581102,0.0000169975,0.000016423],"domain_scores_gemma":[0.9998926,0.000008293379,0.00003468604,0.00001246873,0.00001381584,0.00003817138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001834859,0.00002773945,0.001973082,0.0000875002,0.00001623899,0.0002165545,0.00001970534,0.00006632496,0.9924184,0.0001843991,0.0003323666,0.004474223],"study_design_scores_gemma":[0.00005264389,0.0006138009,0.08813223,0.00004285885,0.00008997898,0.00425519,0.0001142019,0.001195532,0.8929879,0.0006189921,0.011883,0.00001366573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9683362,0.02514929,0.002870413,0.0008728049,0.0001216313,0.00001919436,0.0005312145,0.0001461396,0.001953117],"genre_scores_gemma":[0.9937244,0.00309641,0.0007942538,0.0002471256,0.00004685742,0.00001145854,0.000380384,0.000009484746,0.001689501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001333539,"threshold_uncertainty_score":0.00446111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0646308866844324,"score_gpt":0.3874754253953273,"score_spread":0.3228445387108949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}