{"id":"W4399556172","doi":"10.1016/j.clgc.2024.102137","title":"Predicting Treatment Effects from Surrogate Endpoints in Historical Trials in First-Line Metastatic Castration-Resistant Prostate Cancer","year":2024,"lang":"en","type":"review","venue":"Clinical Genitourinary Cancer","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"EVERSANA (Canada)","funders":"Pfizer","keywords":"Medicine; Prostate cancer; Surrogate endpoint; Oncology; Internal medicine; Clinical trial; Castration; Clinical endpoint; Cancer; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008579444,0.001255793,0.003911428,0.001444833,0.0001007274,0.00139571,0.0011532,0.000995645,0.001815435],"category_scores_gemma":[0.01314638,0.00039239,0.003998462,0.001739179,0.0002986783,0.0009971319,0.0004944088,0.001660858,0.0003790339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007986219,"about_ca_system_score_gemma":0.001235745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001022602,"about_ca_topic_score_gemma":0.002121701,"domain_scores_codex":[0.9971718,0.001933541,0.0003307898,0.0001803927,0.000336924,0.00004653307],"domain_scores_gemma":[0.9873235,0.01134762,0.000834867,0.0001567725,0.0002858076,0.00005151962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0006729901,0.00007350236,0.0009846754,0.08206621,0.005418533,0.00005064116,0.00004778763,0.01172658,0.0005002962,0.003044339,0.003705319,0.8917092],"study_design_scores_gemma":[0.002743028,0.006527704,0.02632768,0.2429085,0.07160261,0.002162903,0.0003320803,0.04012324,0.004917328,0.03895741,0.56288,0.0005174097],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006711393,0.9973658,0.001275474,0.0001262579,0.00005530894,0.00003783317,0.0000903578,0.00001251026,0.0003654042],"genre_scores_gemma":[0.01704178,0.9802595,0.001995368,0.000192988,0.00006909778,0.000090741,0.0001749747,0.000007217092,0.0001682977],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008579444,"threshold_uncertainty_score":0.04537302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3290512161179735,"score_gpt":0.5274228000287672,"score_spread":0.1983715839107937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}