{"id":"W4399556982","doi":"10.1016/j.joca.2024.06.003","title":"Serum ARGS-aggrecan in a phase 2 clinical trial targeting osteoarthritis","year":2024,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"GlaxoSmithKline","keywords":"Aggrecan; Osteoarthritis; Medicine; Phase (matter); Internal medicine; Chemistry; Articular cartilage; Pathology; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001353603,0.001076923,0.001233841,0.0002522798,0.0001587432,0.0005919179,0.0003651812,0.0008092826,0.00267607],"category_scores_gemma":[0.0006917429,0.0003143849,0.0006381464,0.000222712,0.0003582848,0.0002453814,0.0001739401,0.001004892,0.0004996606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003826242,"about_ca_system_score_gemma":0.0009442366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006279536,"about_ca_topic_score_gemma":0.00189798,"domain_scores_codex":[0.9995939,0.0002209437,0.00002275338,0.00004934088,0.00004668775,0.00006628774],"domain_scores_gemma":[0.9996856,0.00005355668,0.00009875857,0.00001673749,0.00003098305,0.0001142528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.798412,0.02418733,0.002846285,0.001315413,0.0006906019,0.0002449743,0.000107646,0.001217722,0.09327541,0.0001651301,0.002193014,0.07534438],"study_design_scores_gemma":[0.5083579,0.4743833,0.00761433,0.00004328744,0.0003509955,0.000211842,0.00003488206,0.0008135246,0.006107751,0.00009308395,0.001966197,0.00002280548],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929754,0.002975328,0.0004133685,0.0003827472,0.0001411505,0.001447661,0.0004632697,0.00009364729,0.001107474],"genre_scores_gemma":[0.9859044,0.002966309,0.001855491,0.00085369,0.0002505965,0.002127226,0.001149739,0.00001815448,0.004874405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00267607,"threshold_uncertainty_score":0.00895232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02599200629814742,"score_gpt":0.3291308250133254,"score_spread":0.303138818715178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}