{"id":"W4399565785","doi":"10.1073/pnas.2320995121","title":"RNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Ministerio de Ciencia e Innovación; Consejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Junta de Castilla y León; KWF Kankerbestrijding; Universidad de Sevilla","keywords":"Meiosis; Crossover; Ubiquitin ligase; Biology; Genetics; Andrology; Cell biology; Computer science; Medicine; Gene; Ubiquitin; Artificial intelligence","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001684604,0.0004201453,0.0002246649,0.0006132422,0.0003131477,0.0004500729,0.0003482326,0.0004984829,0.002234105],"category_scores_gemma":[0.0001425551,0.0004081075,0.0003100348,0.0002185428,0.0003170067,0.0002260036,0.000288119,0.0004384598,0.0009508568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005595418,"about_ca_system_score_gemma":0.0002822062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001240303,"about_ca_topic_score_gemma":0.001828244,"domain_scores_codex":[0.9996961,0.0000335904,0.00003468087,0.00009899091,0.00008186139,0.00005471303],"domain_scores_gemma":[0.9997624,0.00001280606,0.00008880577,0.00001981347,0.00001504994,0.0001012042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001443942,0.00001784961,0.0006956709,0.00002428109,0.000004068941,0.00007942125,0.00001318052,0.00003881136,0.9975291,0.0001899518,0.00003729413,0.001226022],"study_design_scores_gemma":[0.00003655603,0.0001771647,0.02958675,0.00001826682,0.0000306808,0.0009037077,0.00004907442,0.0009752924,0.9602655,0.0001213262,0.007825503,0.00001012935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990824,0.00166708,0.00464549,0.0001084517,0.00002801535,0.00002750862,0.0008208403,0.0001875384,0.001691079],"genre_scores_gemma":[0.9855805,0.0007169822,0.003189759,0.00006539534,0.000007533087,0.00004898418,0.0009571955,0.00005862649,0.009375071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002234105,"threshold_uncertainty_score":0.007473826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02784777757587941,"score_gpt":0.2992330443138834,"score_spread":0.271385266738004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}