{"id":"W4399567425","doi":"10.1038/s41586-024-07532-8","title":"DNA mismatch and damage patterns revealed by single-molecule sequencing","year":2024,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke; Hospital for Sick Children","funders":"Common Fund; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Cancer Institute; Damon Runyon Cancer Research Foundation; Canadian Institutes of Health Research; National Institute of Child Health and Human Development; Fondation Brain Canada; NYU Grossman School of Medicine; Stand Up To Cancer; National Institutes of Health; Bristol-Myers Squibb; York University; Icahn School of Medicine at Mount Sinai; Hospital for Sick Children; National Institute on Aging","keywords":"DNA damage; DNA; Genome; Genetics; DNA sequencing; Biology; Computational biology; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000642377,0.0001151438,0.00008295703,0.0000220442,0.00003796563,0.00008651673,0.00008915504,0.0005490163,0.00001467097],"category_scores_gemma":[0.00005189404,0.0001107776,0.00004143939,0.00005319837,0.00002338973,0.000002492381,0.00007854071,0.0004078086,0.000003991131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002879156,"about_ca_system_score_gemma":0.00005310428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001749247,"about_ca_topic_score_gemma":0.00003983316,"domain_scores_codex":[0.9993592,0.00001365153,0.00009199674,0.0003045641,0.00007332883,0.0001572396],"domain_scores_gemma":[0.9996852,0.00001786801,0.00001848414,0.000184349,0.00002886199,0.00006524003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008887332,0.000009747133,0.0005914011,0.00006521989,0.00002630607,0.00002837146,0.00004977947,0.000002334145,0.9379417,0.00009981565,0.05986897,0.001307505],"study_design_scores_gemma":[0.0003384974,0.0001817391,0.000650788,0.0001088636,0.00004086594,0.00005432918,0.00008962524,0.0001789364,0.6567055,0.000198064,0.3411132,0.0003395574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794714,0.01749415,0.0003360104,0.0007880479,0.0003039996,0.00008833854,0.0002256158,0.00002003149,0.001272338],"genre_scores_gemma":[0.9959619,0.000690786,0.0001859788,0.001682894,0.0002890952,0.00000588432,0.0002478486,0.00002666334,0.0009089389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2812443,"threshold_uncertainty_score":0.4517378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005534845489150271,"score_gpt":0.236556342005607,"score_spread":0.2310214965164567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}