{"id":"W4399567599","doi":"10.1021/acs.estlett.4c00342","title":"Biotransformation of 6PPD-quinone <i>In Vitro</i> Using RTL-W1 Cell Line","year":2024,"lang":"en","type":"article","venue":"Environmental Science & Technology Letters","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Global Institute for Water Security; University of Saskatchewan","funders":"Fisheries and Oceans Canada; Natural Sciences and Engineering Research Council of Canada; Global Water Futures; University of Saskatchewan","keywords":"Biotransformation; Quinone; In vitro; Chemistry; Cell culture; Stereochemistry; Combinatorial chemistry; Biology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001885621,0.0003481073,0.0002503777,0.0001184173,0.0001582787,0.0002241717,0.000159129,0.000168514,0.0006275884],"category_scores_gemma":[0.00009724106,0.0001181863,0.0004113437,0.0001862476,0.0001566809,0.0001492943,0.0001748928,0.0003641057,0.0004132712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003357654,"about_ca_system_score_gemma":0.0002129982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004438775,"about_ca_topic_score_gemma":0.004034526,"domain_scores_codex":[0.9998245,0.00002859893,0.0000203431,0.00004752325,0.00004856164,0.00003059327],"domain_scores_gemma":[0.9999142,0.00001749148,0.00002489376,0.00001687836,0.0000189295,0.000007536033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002520159,0.00001181886,0.0003459996,0.00001690829,0.000003540883,0.00002491557,0.00001479559,0.00005965618,0.9990619,0.00002143831,0.00002077965,0.0003930122],"study_design_scores_gemma":[0.000002863888,0.0002187862,0.003383435,0.000001595082,0.000009956117,0.00007410971,0.00001968794,0.0005699823,0.9950134,0.000009844404,0.0006922336,0.000004039603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913945,0.0008167599,0.005208345,0.00008072949,0.00002479599,0.000055525,0.001193091,0.0001136344,0.001112665],"genre_scores_gemma":[0.9884447,0.0008452921,0.005555919,0.00004950739,0.000007926072,0.00005597428,0.002348642,0.00002594679,0.002666143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004438775,"threshold_uncertainty_score":0.008825898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006163874147102635,"score_gpt":0.2475867353484417,"score_spread":0.2414228612013391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}