{"id":"W4399567599","doi":"10.1021/acs.estlett.4c00342","title":"Biotransformation of 6PPD-quinone <i>In Vitro</i> Using RTL-W1 Cell Line","year":2024,"lang":"en","type":"article","venue":"Environmental Science & Technology Letters","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Global Institute for Water Security; University of Saskatchewan","funders":"Fisheries and Oceans Canada; Natural Sciences and Engineering Research Council of Canada; Global Water Futures; University of Saskatchewan","keywords":"Biotransformation; Quinone; In vitro; Chemistry; Cell culture; Stereochemistry; Combinatorial chemistry; Biology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002195219,0.0001017683,0.00009135007,0.0003566163,0.0000709645,0.00001474248,0.0002971775,0.000108102,0.00002028984],"category_scores_gemma":[0.000006167683,0.00009624435,0.0000432869,0.0005302716,0.001177104,0.00002132553,0.0001504975,0.0001437186,0.00001825304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007372299,"about_ca_system_score_gemma":0.00003718435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000140853,"about_ca_topic_score_gemma":0.000001368966,"domain_scores_codex":[0.9989545,0.0000137036,0.0001735894,0.0003349656,0.0002099026,0.0003133454],"domain_scores_gemma":[0.999709,0.000004763624,0.00002811015,0.0002173974,0.000002543964,0.00003818825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001369697,0.00004390896,0.0006382234,0.00001300488,0.000003592133,0.00001335608,0.00002351372,0.0001697119,0.9951023,0.000009640723,0.00001660656,0.003952465],"study_design_scores_gemma":[0.0001449626,0.00008198409,0.000150708,0.00001499671,0.000004597218,0.000009999535,0.000118089,0.001291726,0.9962054,0.00001106374,0.001865751,0.0001007442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952993,0.0006556878,0.002657193,0.001024115,0.00005379577,0.0001322102,0.0000201721,0.00001741747,0.0001401133],"genre_scores_gemma":[0.9985039,0.0001606534,0.001082619,0.0001673016,0.00002379713,0.000007006911,0.00001924355,0.00000981655,0.00002567301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003851721,"threshold_uncertainty_score":0.433709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006163874147102635,"score_gpt":0.2475867353484417,"score_spread":0.2414228612013391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}