{"id":"W4399571900","doi":"10.3390/biomedicines12061300","title":"DREAM On, DREAM Off: A Review of the Estrogen Paradox in Luminal A Breast Cancers","year":2024,"lang":"en","type":"review","venue":"Biomedicines","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Precursory Research for Embryonic Science and Technology; Canadian Cancer Society Research Institute; Alberta Cancer Foundation","keywords":"Estrogen; Breast cancer; Aromatase; Estrogen receptor; Internal medicine; Endocrinology; Hormone; Estrogen receptor alpha; Cancer research; Biology; Medicine; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003080092,0.0004478527,0.001132864,0.000152155,0.00002875311,0.000007048464,0.0004731925,0.0004267139,0.00001105693],"category_scores_gemma":[0.00006995072,0.0002330315,0.0006307079,0.0007045718,0.000273769,0.000001379981,0.0001485906,0.0003650583,0.00003035891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007891314,"about_ca_system_score_gemma":0.0007721978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000760951,"about_ca_topic_score_gemma":0.000008137707,"domain_scores_codex":[0.9981354,0.0001731384,0.0006397113,0.0004991458,0.0002633738,0.0002892587],"domain_scores_gemma":[0.998899,0.00002578699,0.0002933688,0.0006413905,0.0000478088,0.00009264212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003335522,0.0001139198,0.00002323463,0.124614,0.0007356083,0.00006791297,0.00002221491,2.658104e-7,0.0002612472,0.00004488823,0.07014467,0.8039387],"study_design_scores_gemma":[0.000161034,0.0002333421,0.000006101935,0.1644894,0.001096856,0.0004246734,0.000006817518,6.439176e-7,0.00007861821,0.000003307795,0.8332981,0.0002011157],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002118204,0.9972304,2.187155e-7,0.000243476,0.0007535322,0.0009277335,0.0001375028,0.00001051721,0.0004848137],"genre_scores_gemma":[0.00008906924,0.9980472,0.000007183252,0.0002111171,0.0007082596,0.0000927055,0.0002688708,0.00005485679,0.0005207739],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8037376,"threshold_uncertainty_score":0.9502747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01168958887929081,"score_gpt":0.3180214925634433,"score_spread":0.3063319036841524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}