{"id":"W4399571900","doi":"10.3390/biomedicines12061300","title":"DREAM On, DREAM Off: A Review of the Estrogen Paradox in Luminal A Breast Cancers","year":2024,"lang":"en","type":"review","venue":"Biomedicines","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Precursory Research for Embryonic Science and Technology; Canadian Cancer Society Research Institute; Alberta Cancer Foundation","keywords":"Estrogen; Breast cancer; Aromatase; Estrogen receptor; Internal medicine; Endocrinology; Hormone; Estrogen receptor alpha; Cancer research; Biology; Medicine; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005496576,0.0007059214,0.001113964,0.002633014,0.0003108617,0.000873925,0.0007978783,0.0009589028,0.002225626],"category_scores_gemma":[0.001060003,0.0002774711,0.0005081127,0.002664098,0.0004240483,0.001327299,0.0005946105,0.00164283,0.001060058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006804558,"about_ca_system_score_gemma":0.001250364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001093774,"about_ca_topic_score_gemma":0.002013896,"domain_scores_codex":[0.9998488,0.00003064017,0.00003195976,0.00002822958,0.00004636506,0.00001396745],"domain_scores_gemma":[0.9995302,0.0002673211,0.00005236431,0.00001099044,0.00009775871,0.00004151078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001003367,0.00006423896,0.0001961259,0.03398492,0.0001287127,0.0002535151,0.0001088226,0.0003456465,0.001058517,0.003800041,0.06708506,0.8928741],"study_design_scores_gemma":[0.00001325454,0.0001038978,0.0008796837,0.008671373,0.0001715041,0.001346014,0.00008131707,0.00006204332,0.0002281794,0.001842392,0.986579,0.000021334],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006643781,0.9989071,0.00006056562,0.0002939187,0.0002654176,0.000002077297,0.00001223015,0.000004780999,0.000387636],"genre_scores_gemma":[0.0003572886,0.9988612,0.0001035888,0.0002411567,0.0002025513,0.000003191624,0.00001978634,0.000001097435,0.0002101579],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002633014,"threshold_uncertainty_score":0.007445514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01168958887929081,"score_gpt":0.3180214925634433,"score_spread":0.3063319036841524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}