{"id":"W4399572127","doi":"10.3389/fonc.2024.1394543","title":"Hemophagocytic lymphohistiocytosis/cytokine release syndrome secondary to neoadjuvant pembrolizumab for triple-negative breast cancer: a case study","year":2024,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"CNS Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Pembrolizumab; Medicine; Breast cancer; Context (archaeology); Triple-negative breast cancer; Oncology; Tumor-infiltrating lymphocytes; Chemotherapy; Cancer; Neoadjuvant therapy; Internal medicine; Nivolumab; Cytokine release syndrome; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002789881,0.0004027891,0.001186642,0.0007239876,0.0001343675,0.00004119381,0.0001335825,0.0002050499,0.0001921785],"category_scores_gemma":[0.0001155782,0.0003536041,0.000243635,0.0006855723,0.0001025301,0.0001049993,0.00009178094,0.0002436767,0.00003526769],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007016866,"about_ca_system_score_gemma":0.002145409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003289281,"about_ca_topic_score_gemma":0.001389676,"domain_scores_codex":[0.9974732,0.0001369581,0.0006386294,0.0009016999,0.0002282178,0.0006213344],"domain_scores_gemma":[0.9986163,0.0003384467,0.00008976408,0.000417192,0.0001194814,0.0004188327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00655782,0.005085208,0.03259477,0.0005043999,0.001575704,0.2638232,0.005025592,0.0001500842,0.000051775,0.00004717484,0.08215679,0.6024274],"study_design_scores_gemma":[0.1306393,0.03646333,0.3661536,0.001927315,0.00558991,0.3318414,0.02817911,0.01664185,0.0006269103,0.0006191941,0.07935333,0.001964752],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815117,0.004926268,0.0005236579,0.003750431,0.003335883,0.004590445,0.0009225114,0.000147042,0.0002921386],"genre_scores_gemma":[0.9902854,0.0002221548,0.003091163,0.000937043,0.0002502732,0.004139331,0.00004509515,0.00008452393,0.0009450276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6004627,"threshold_uncertainty_score":0.9998916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01556828605318132,"score_gpt":0.3275343895801461,"score_spread":0.3119661035269647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}