{"id":"W4399575038","doi":"10.1186/s40345-024-00341-y","title":"Exploring the genetics of lithium response in bipolar disorders","year":2024,"lang":"en","type":"article","venue":"International Journal of Bipolar Disorders","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders; McGill University; Douglas Mental Health University Institute; McGill University Health Centre; Dalhousie University; Montreal Neurological Institute and Hospital","funders":"Cilag; Instituto de Salud Carlos III; Canadian Institutes of Health Research; National Health and Medical Research Council; Allergan; Research Nova Scotia; Medical Research Council; Neuraxpharm; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Vetenskapsrådet; Genome Atlantic; Westfälische Wilhelms-Universität Münster; National Institute of Mental Health; Stockholms Läns Landsting; Gedeon Richter; Generalitat de Catalunya; Bundesministerium für Bildung und Forschung; Sunovion; Centres de Recerca de Catalunya; H. Lundbeck A/S; U.S. Department of Veterans Affairs; University of New South Wales; Servier; Karolinska Institutet; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Fondation FondaMental; Deutsche Forschungsgemeinschaft; Sanofi; Eli Lilly and Company","keywords":"Bipolar disorder; Mania; Lithium (medication); Depression (economics); Psychiatry; Medicine; Suicidal ideation; Mood disorders; Internal medicine; Neurology; Family history; Schizophrenia (object-oriented programming); Cohort; Poison control; Anxiety; Injury prevention","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008127853,0.0001963837,0.0002900955,0.0007645708,0.00003925307,0.00005256666,0.0003960616,0.00006462116,0.0000662505],"category_scores_gemma":[0.0002235718,0.0001364683,0.0003631869,0.0004309163,0.0001538806,0.0002929882,0.00007468074,0.0004960824,0.00001455614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001607667,"about_ca_system_score_gemma":0.0002832828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000167067,"about_ca_topic_score_gemma":0.0004342976,"domain_scores_codex":[0.9979289,0.0001612353,0.0007047671,0.0001881161,0.0007916018,0.0002254125],"domain_scores_gemma":[0.998943,0.0003723219,0.0001799468,0.000219954,0.000189301,0.00009548913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002666666,0.0008626184,0.2566946,0.0001021695,0.001417335,0.0000823512,0.004426558,0.0003820173,0.004564355,0.0007458311,0.0001833121,0.7278723],"study_design_scores_gemma":[0.002006416,0.0008870229,0.4686933,0.0005242597,0.0002163265,0.0002283903,0.001032655,0.0005753871,0.001657654,0.001293048,0.5227042,0.0001813258],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7394387,0.24682,0.0007514729,0.01064037,0.001796787,0.000243315,0.00003085218,0.00002280343,0.0002556284],"genre_scores_gemma":[0.9267085,0.07261121,0.0002966735,0.00007636988,0.0001561582,0.00001101091,0.000006461067,0.00003680431,0.00009681485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7276909,"threshold_uncertainty_score":0.5565016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03183097847758343,"score_gpt":0.2981131912482138,"score_spread":0.2662822127706304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}