{"id":"W4399575038","doi":"10.1186/s40345-024-00341-y","title":"Exploring the genetics of lithium response in bipolar disorders","year":2024,"lang":"en","type":"article","venue":"International Journal of Bipolar Disorders","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders; McGill University; Douglas Mental Health University Institute; McGill University Health Centre; Dalhousie University; Montreal Neurological Institute and Hospital","funders":"Cilag; Instituto de Salud Carlos III; Canadian Institutes of Health Research; National Health and Medical Research Council; Allergan; Research Nova Scotia; Medical Research Council; Neuraxpharm; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Vetenskapsrådet; Genome Atlantic; Westfälische Wilhelms-Universität Münster; National Institute of Mental Health; Stockholms Läns Landsting; Gedeon Richter; Generalitat de Catalunya; Bundesministerium für Bildung und Forschung; Sunovion; Centres de Recerca de Catalunya; H. Lundbeck A/S; U.S. Department of Veterans Affairs; University of New South Wales; Servier; Karolinska Institutet; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Fondation FondaMental; Deutsche Forschungsgemeinschaft; Sanofi; Eli Lilly and Company","keywords":"Bipolar disorder; Mania; Lithium (medication); Depression (economics); Psychiatry; Medicine; Suicidal ideation; Mood disorders; Internal medicine; Neurology; Family history; Schizophrenia (object-oriented programming); Cohort; Poison control; Anxiety; Injury prevention","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007400093,0.0004042947,0.0002898489,0.0008065685,0.00053611,0.0006419148,0.0003295505,0.0005006567,0.002003913],"category_scores_gemma":[0.002009792,0.0001648704,0.0006060055,0.001318377,0.0003763379,0.0002120776,0.0004074469,0.0004635772,0.0001621678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005120609,"about_ca_system_score_gemma":0.0003428454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007276687,"about_ca_topic_score_gemma":0.008592595,"domain_scores_codex":[0.9994382,0.0002045772,0.0000510135,0.000154032,0.00008719465,0.00006499747],"domain_scores_gemma":[0.999001,0.0002929933,0.0004866701,0.00005882857,0.00006770778,0.00009276665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005003206,0.00003986468,0.9877979,0.00004074805,0.000347487,0.0005862038,0.0002489417,0.00029196,0.002126922,0.0002340157,0.0003627279,0.007422957],"study_design_scores_gemma":[0.00003359437,0.0001146112,0.9964315,0.00004227872,0.0002031632,0.0008819507,0.0001511628,0.0008235993,0.000298453,0.000569555,0.0004404758,0.000009650299],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997134,0.0007551314,0.0005075723,0.0002498036,0.00001043475,0.0000155248,0.0006300965,0.000009721119,0.0006876953],"genre_scores_gemma":[0.9987046,0.0002179682,0.0004650059,0.0001025421,0.00001287184,0.00001302128,0.0003543418,0.00000550154,0.0001242034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007276687,"threshold_uncertainty_score":0.01446867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03183097847758343,"score_gpt":0.2981131912482138,"score_spread":0.2662822127706304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}