{"id":"W4399577009","doi":"10.1038/s41586-024-07533-7","title":"Genetic drivers and cellular selection of female mosaic X chromosome loss","year":2024,"lang":"en","type":"article","venue":"Nature","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Institute of Mental Health; Boston Scientific Corporation; Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; Medical Research Council; Broad Institute; University of California, Irvine; Genentech; Universitätsklinikum Hamburg-Eppendorf; National Institutes of Health; Faculty of Health and Medical Sciences, University of Western Australia; Tartu Ülikool; U.S. Department of Veterans Affairs; University of Toronto; Medizinischen Hochschule Hannover; Eesti Teadusagentuur; Gentofte Hospital; Japan Society for the Promotion of Science; European Regional Development Fund; European Commission; Deutschen Konsortium für Translationale Krebsforschung; Japan Agency for Medical Research and Development; Amgen; Deutsches Krebsforschungszentrum","keywords":"Mosaic; Somatic cell; Biology; Genetics; Chromosome; Selection (genetic algorithm); X chromosome; Chromosome number; Evolutionary biology; Karyotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001823016,0.0002252657,0.0002688632,0.0006159166,0.0001921969,0.0004625723,0.0003107355,0.0003632059,0.002539292],"category_scores_gemma":[0.0003735119,0.0002285394,0.0001429096,0.000208473,0.0004128058,0.0002782779,0.0004999161,0.000412818,0.0003659567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002285038,"about_ca_system_score_gemma":0.0001793483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002580532,"about_ca_topic_score_gemma":0.0003450699,"domain_scores_codex":[0.9998258,0.00003267416,0.0000126694,0.00002897173,0.00005741274,0.00004253398],"domain_scores_gemma":[0.9997905,0.00005782503,0.00005449198,0.00003435649,0.00001263363,0.00005023202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000239479,0.00003525366,0.006385108,0.00002715645,0.00001195698,0.001938453,0.00005958859,0.0001961467,0.9822907,0.005365222,0.0001870975,0.003264021],"study_design_scores_gemma":[0.00006706044,0.0003802861,0.1342027,0.00001945761,0.00006985816,0.02759219,0.0005732202,0.00353485,0.8193711,0.003320563,0.0108382,0.0000304932],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927476,0.000925687,0.00208059,0.0002103946,0.00002521542,0.00001454303,0.0003283935,0.0000843135,0.003583259],"genre_scores_gemma":[0.9980947,0.0002830855,0.0002558972,0.00002816552,0.000009242488,0.000008661013,0.0001404286,0.00001792293,0.001161863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002539292,"threshold_uncertainty_score":0.008494735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004982927456645342,"score_gpt":0.2420392384040967,"score_spread":0.2370563109474514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}