{"id":"W4399577193","doi":"10.1016/j.chom.2024.05.015","title":"Antibiotic resistance: A key microbial survival mechanism that threatens public health","year":2024,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":181,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Canadian Food Inspection Agency","keywords":"Biology; Antibiotics; Antibiotic resistance; Bacteria; Biotechnology; Resistance (ecology); Mechanism (biology); Disease; Microbiology; Genetics; Ecology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005425603,0.0004124393,0.0003923577,0.0001123651,0.0002166924,0.0003442453,0.0004886399,0.0003102633,0.000111961],"category_scores_gemma":[0.0000277635,0.0003983963,0.0002396486,0.000246573,0.0001967284,0.00001583081,0.0002518405,0.0002513572,0.0002360941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000116743,"about_ca_system_score_gemma":0.0005409504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003713345,"about_ca_topic_score_gemma":0.0002416728,"domain_scores_codex":[0.9973698,0.0001647374,0.0004027442,0.0009846736,0.000193029,0.0008850169],"domain_scores_gemma":[0.9987432,0.00002323146,0.0001366501,0.0007667549,0.00009275783,0.0002373723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004820947,0.00009234609,0.0007193423,0.0003734491,0.00007478617,0.00004517727,0.0001816296,2.34015e-7,0.9684239,0.0009758713,0.02887903,0.0001860276],"study_design_scores_gemma":[0.0005274157,0.000168397,0.001934157,0.0002250744,0.00003090336,0.00004699681,0.000270932,0.000004754168,0.6803427,0.0001144614,0.3157513,0.0005829042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687811,0.01392723,0.004913757,0.00265084,0.002719996,0.0005824348,0.0003075186,0.000166326,0.005950804],"genre_scores_gemma":[0.9783146,0.002140701,0.002101379,0.0006338698,0.0004757692,0.000003063022,0.0004325258,0.0001215271,0.01577653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2880812,"threshold_uncertainty_score":0.9998468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02100419228654032,"score_gpt":0.2536025130135399,"score_spread":0.2325983207269996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}