{"id":"W4399580925","doi":"10.1128/mbio.00477-24","title":"CRISPR-Cas9 high-throughput screening to study drug resistance in <i>Leishmania infantum</i>","year":2024,"lang":"en","type":"article","venue":"mBio","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research; Alliance de recherche numérique du Canada; Université Laval","keywords":"Leishmania infantum; CRISPR; Drug resistance; Virology; Leishmania; Biology; Wolbachia; Computational biology; Drug discovery; Leishmaniasis; Microbiology; Bioinformatics; Computer science; Immunology; Genetics; Bacteria; Gene; World Wide Web; Visceral leishmaniasis; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003951012,0.0004603434,0.0005320918,0.0004335887,0.0002066281,0.000417233,0.0004718517,0.0003877902,0.001447429],"category_scores_gemma":[0.000248776,0.0002007575,0.0004379734,0.0003102287,0.0001905681,0.0001368614,0.0003046621,0.0004572935,0.0005198982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003723366,"about_ca_system_score_gemma":0.0002122493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009214801,"about_ca_topic_score_gemma":0.001481244,"domain_scores_codex":[0.9996729,0.00006020763,0.00003832786,0.00007810535,0.0001079188,0.00004243276],"domain_scores_gemma":[0.9998571,0.00004407923,0.00003257168,0.00001967172,0.00002543705,0.00002128613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004376115,0.00003228031,0.0002254603,0.00005488767,0.00001335764,0.00004857809,0.000009948826,0.0003575955,0.9968417,0.0001197045,0.0001520314,0.002100885],"study_design_scores_gemma":[0.00002387234,0.0003125097,0.002391683,0.000006240827,0.0000423966,0.0002629546,0.00002073425,0.005441112,0.9866734,0.00006848761,0.004742696,0.00001403973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8819826,0.001870566,0.101902,0.0003469973,0.00008203171,0.0005904926,0.005521409,0.002463785,0.005240241],"genre_scores_gemma":[0.9424424,0.0008475478,0.04714753,0.000149047,0.00001109786,0.0002800731,0.003717532,0.0002368775,0.005167877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001447429,"threshold_uncertainty_score":0.004842162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02684136836177339,"score_gpt":0.3348564566836661,"score_spread":0.3080150883218927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}