{"id":"W4399586224","doi":"10.1038/s41598-024-63902-2","title":"Circulating immunoglobulins and transient lymphocytopenia in a sub-study of CAPRISA 012B, testing HIV monoclonal antibodies in a phase 1 trial","year":2024,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"European and Developing Countries Clinical Trials Partnership; National Institute of Allergy and Infectious Diseases; Poliomyelitis Research Foundation; Medical Research Council; South African Medical Research Council; National Research Foundation; Department of Science and Innovation, South Africa; National Institutes of Health; National Science Foundation","keywords":"Lymphocytopenia; Immunology; Antibody; Lymphocyte; Medicine; Leukopenia; Cytokine; Internal medicine; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00167742,0.001021237,0.0006848132,0.0002949956,0.0003581367,0.001022184,0.000696442,0.001173884,0.002723243],"category_scores_gemma":[0.001455939,0.0004248234,0.0005768968,0.0002258444,0.0004745615,0.0004472458,0.0002010394,0.002154841,0.0004858618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007196314,"about_ca_system_score_gemma":0.00114234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007724355,"about_ca_topic_score_gemma":0.001402721,"domain_scores_codex":[0.9995565,0.0002206203,0.00001858097,0.00006057287,0.0000547201,0.00008904773],"domain_scores_gemma":[0.9991028,0.0001977337,0.0001635528,0.00005313993,0.00008380647,0.0003989214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6260123,0.0648592,0.02659006,0.001706143,0.001761749,0.001257985,0.0006492305,0.00154865,0.08087024,0.0004100795,0.008343511,0.1859908],"study_design_scores_gemma":[0.2288773,0.7037799,0.04981811,0.00008695261,0.0006769458,0.001298114,0.0001684144,0.001617081,0.007667383,0.0002045115,0.005765946,0.00003931143],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943852,0.002061116,0.0002001025,0.0003359189,0.0000610783,0.0007529259,0.000402676,0.0000637813,0.001737191],"genre_scores_gemma":[0.9945422,0.0008265355,0.0003547338,0.0009790488,0.0001384185,0.000869499,0.0008071929,0.00001017526,0.001472261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002723243,"threshold_uncertainty_score":0.009110153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0245903111176906,"score_gpt":0.2810845942122651,"score_spread":0.2564942830945745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}