{"id":"W4399589660","doi":"10.1093/pnasnexus/pgae234","title":"A leak K+ channel TWK-40 sustains the rhythmic motor program","year":2024,"lang":"en","type":"article","venue":"PNAS Nexus","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"H2020 European Research Council; National Key Research and Development Program of China; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Rhythm; Leak; Channel (broadcasting); Environmental science; Engineering; Electrical engineering; Medicine; Internal medicine; Environmental engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007333117,0.0002566203,0.0002180366,0.0001494322,0.0001725888,0.0002225402,0.0003413025,0.0002775333,0.0008223461],"category_scores_gemma":[0.0001056543,0.0001302935,0.0002121684,0.00006974582,0.000270563,0.0002517159,0.0003495622,0.0004776068,0.0003156839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003737821,"about_ca_system_score_gemma":0.0002654041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006708328,"about_ca_topic_score_gemma":0.001147523,"domain_scores_codex":[0.9999181,0.000004185157,0.000008391626,0.00002140703,0.0000255668,0.00002250291],"domain_scores_gemma":[0.9998318,0.00001317336,0.00004626886,0.00002274797,0.00001623231,0.00006978758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003247736,0.000005869462,0.00009549368,0.00001116438,0.000001301811,0.00002515843,0.0000033614,0.00003124658,0.9994416,0.00003737483,0.00001402128,0.0003009866],"study_design_scores_gemma":[0.00003080194,0.0001364236,0.007503716,0.00001081209,0.00001357317,0.0002508754,0.00003973254,0.003262664,0.9869773,0.0001291699,0.001636378,0.000008567481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997348,0.0002030168,0.00163349,0.00005321288,0.00001618589,0.000006595691,0.0001590444,0.0001206214,0.0004598404],"genre_scores_gemma":[0.9971374,0.0001352022,0.0008024087,0.00002862658,0.000004595439,0.00001663548,0.000225083,0.0000368638,0.001613144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008223461,"threshold_uncertainty_score":0.002750993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01289417722389286,"score_gpt":0.2691640700788281,"score_spread":0.2562698928549352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}