{"id":"W4399610274","doi":"10.1016/s1474-4422(24)00206-0","title":"Tenecteplase versus alteplase for thrombolysis in patients selected by use of perfusion imaging within 4·5 h of onset of ischaemic stroke (TASTE): a multicentre, randomised, controlled, phase 3 non-inferiority trial","year":2024,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Health and Medical Research Council; Boehringer Ingelheim","keywords":"Tenecteplase; Thrombolysis; Medicine; Stroke (engine); Ischaemic stroke; Randomized controlled trial; Cardiology; Tissue plasminogen activator; Internal medicine; Perfusion scanning; Anesthesia; Perfusion; Ischemia; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004833021,0.001634523,0.002980433,0.0003875471,0.0003934938,0.00109987,0.0008751158,0.001835572,0.005041191],"category_scores_gemma":[0.004467947,0.0005069195,0.002458838,0.0004684545,0.001187141,0.001069342,0.0005032917,0.001836932,0.000601862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006183812,"about_ca_system_score_gemma":0.001122734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003910773,"about_ca_topic_score_gemma":0.0009775166,"domain_scores_codex":[0.9978542,0.001399418,0.000203922,0.0002362638,0.00009403464,0.0002121661],"domain_scores_gemma":[0.9979882,0.0006616611,0.0006250233,0.0001638863,0.0001273761,0.0004337744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9911459,0.0019546,0.0004772511,0.0004507623,0.0006395464,0.00002488993,0.00003345482,0.0001283242,0.001210509,0.00006168018,0.0001754351,0.00369761],"study_design_scores_gemma":[0.9641426,0.03377463,0.001045057,0.00002226225,0.0004342782,0.00002047631,0.00001149027,0.0001499978,0.0001555705,0.0001118208,0.0001242487,0.000007577631],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859691,0.002828109,0.0009003418,0.0006180675,0.0004177016,0.007239049,0.0006185882,0.00006365724,0.001345437],"genre_scores_gemma":[0.9861795,0.001118496,0.001557968,0.0009407744,0.0003592271,0.008263973,0.0004812412,0.00001376897,0.001084922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005041191,"threshold_uncertainty_score":0.02555978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068089647674481,"score_gpt":0.297372187907688,"score_spread":0.2766912914309432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}