{"id":"W4399614361","doi":"10.1038/s41598-024-64346-4","title":"Forward programming of hiPSCs towards beta-like cells using Ngn3, Pdx1, and MafA","year":2024,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg; Horizon 2020 Framework Programme; University of Alberta; Deutsche Forschungsgemeinschaft; Universitätsklinikum Tübingen; University of Galway; European Commission; National University of Ireland","keywords":"PDX1; Induced pluripotent stem cell; Insulin; Biology; Transplantation; Stem cell; Progenitor cell; Enteroendocrine cell; Population; Endocrinology; Internal medicine; Cell biology; Immunology; Islet; Medicine; Hormone; Embryonic stem cell; Endocrine system; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001783366,0.0004103735,0.0003034839,0.0002450908,0.0001432603,0.0003813968,0.0002402875,0.0001956318,0.0008932882],"category_scores_gemma":[0.0001178238,0.0001199852,0.0002697377,0.0001882248,0.0002080033,0.0001588371,0.0002742859,0.0005552198,0.0002858483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002126277,"about_ca_system_score_gemma":0.0003199101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008096474,"about_ca_topic_score_gemma":0.001504552,"domain_scores_codex":[0.9998558,0.00001197014,0.00002054453,0.00003438007,0.00005239895,0.00002486916],"domain_scores_gemma":[0.9999073,0.00001545057,0.00002886204,0.00001392165,0.00001586019,0.00001870235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003649609,0.00002008523,0.0001302211,0.0000381988,0.00000376419,0.00003685621,0.00002018011,0.0001180606,0.9964474,0.0001159167,0.0000487007,0.002984156],"study_design_scores_gemma":[0.000006105114,0.00008607583,0.0008255596,0.000005883966,0.00001071311,0.0000850821,0.00001351256,0.0007010336,0.9952924,0.00002668716,0.002943446,0.000003641096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9506738,0.002004085,0.0404643,0.0001329151,0.0001286475,0.0002491213,0.0009822241,0.000734388,0.004630565],"genre_scores_gemma":[0.9558506,0.001929544,0.03407506,0.0001477833,0.00001942654,0.0002589099,0.0008880409,0.000196785,0.006633911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008932882,"threshold_uncertainty_score":0.002988398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02899845570245942,"score_gpt":0.2860093763235556,"score_spread":0.2570109206210962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}