{"id":"W4399622071","doi":"10.1038/s41467-024-49424-5","title":"Prostate cancer reshapes the secreted and extracellular vesicle urinary proteomes","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; University of Toronto; Health Sciences Centre; University Health Network","funders":"Common Fund; National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Prostate Cancer Foundation; National Institute on Drug Abuse; Hospital for Sick Children; National Heart, Lung, and Blood Institute; National Institute of Mental Health; NIH Office of the Director; Canadian Institutes of Health Research; Prostate Cancer Canada; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Proteome; Prostate cancer; Microvesicles; Biomarker; Genitourinary system; Extracellular vesicle; Urine; Urinary system; Prostate; Secretory protein; Biomarker discovery; Biology; Population; Cancer; Extracellular; Proteomics; Computational biology; Bioinformatics; Cell biology; Medicine; Secretion; Biochemistry; Gene; Endocrinology; microRNA; Genetics; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003361338,0.0002320472,0.0002575539,0.0006017052,0.0002905841,0.0008142961,0.000136255,0.0002141312,0.0007832189],"category_scores_gemma":[0.0003909169,0.0001668638,0.0003238957,0.0005699052,0.0002781137,0.0003368918,0.0006933672,0.0005112815,0.0003550539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002342443,"about_ca_system_score_gemma":0.0004525304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0013027,"about_ca_topic_score_gemma":0.001657511,"domain_scores_codex":[0.9997438,0.00004906119,0.00001428495,0.00004769007,0.00009208146,0.0000529996],"domain_scores_gemma":[0.9998301,0.00002957764,0.00003583471,0.00003084794,0.00004593911,0.00002766128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001785106,0.0000286618,0.008590513,0.0001572058,0.00005588354,0.0001956998,0.0001749783,0.0003652923,0.9634454,0.000738975,0.0004730096,0.02559578],"study_design_scores_gemma":[0.0000229106,0.00074069,0.2340795,0.00006797099,0.0001560752,0.003295071,0.000671272,0.004100421,0.7182319,0.001252658,0.03731972,0.0000618244],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749475,0.00694526,0.01221848,0.0003388268,0.00006718189,0.00006973391,0.001676339,0.0002221925,0.003514533],"genre_scores_gemma":[0.9884475,0.002181803,0.005270465,0.0001199498,0.00001777098,0.00003142146,0.001103997,0.00006878725,0.002758233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0013027,"threshold_uncertainty_score":0.002620101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01071919962900736,"score_gpt":0.2995577490971121,"score_spread":0.2888385494681048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}