{"id":"W4399623182","doi":"10.7554/elife.93077.2","title":"A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCAH1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo","year":2024,"lang":"en","type":"preprint","venue":"eLife","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Zebrafish; Biology; Cancer research; Tumor microenvironment; Immune system; Microglia; Innate immune system; Context (archaeology); Inflammation; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001839218,0.0006070909,0.0003203013,0.0006002766,0.0002518122,0.000240832,0.0003256255,0.0004694343,0.001870352],"category_scores_gemma":[0.00007949027,0.0002449941,0.0004017075,0.0001639436,0.0004291125,0.000259913,0.0002730182,0.0008864297,0.0004592669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007538742,"about_ca_system_score_gemma":0.0006810206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004607345,"about_ca_topic_score_gemma":0.00735435,"domain_scores_codex":[0.9998273,0.00001006216,0.00001562277,0.00004343761,0.0000587967,0.00004479869],"domain_scores_gemma":[0.9998747,0.000008560454,0.00004671797,0.00001270236,0.00001572267,0.00004149551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005355349,0.00001729583,0.00009127086,0.00002004406,0.000003064066,0.00006848773,0.00001503756,0.00007169577,0.9989999,0.000151962,0.00005451841,0.0004532159],"study_design_scores_gemma":[0.00003375695,0.0004860138,0.002770792,0.00001294536,0.00002947007,0.000376645,0.00004723094,0.001625402,0.9919695,0.0001054099,0.002530264,0.00001257209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983883,0.0006444469,0.01005725,0.0002581789,0.00007685627,0.0001672518,0.002081977,0.0004475603,0.002383577],"genre_scores_gemma":[0.9790803,0.0006910914,0.008130735,0.00007313973,0.000008644946,0.000266982,0.001166683,0.000115803,0.01046665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004607345,"threshold_uncertainty_score":0.009161055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01067506338291189,"score_gpt":0.2672384504363893,"score_spread":0.2565633870534774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}