{"id":"W4399625542","doi":"10.1172/jci165814","title":"C16ORF70/MYTHO promotes healthy aging in C.elegans and prevents cellular senescence in mammals","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Medical Research Council; Associazione Italiana per la Ricerca sul Cancro; NextGenerationEU; Ministero della Salute; National Institute on Aging; Deutsche Forschungsgemeinschaft; Wellcome Trust; Francis Crick Institute; National Institutes of Health; Cancer Research UK; Fondazione AIRC per la ricerca sul cancro ETS","keywords":"Autophagy; Biology; Caenorhabditis elegans; Downregulation and upregulation; Cell biology; Senescence; Gene; Ageing; Oxidative stress; Autophagosome; Genetics; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001633337,0.0003720419,0.000215492,0.0004297931,0.0002226033,0.0001925536,0.000236426,0.0002928751,0.001573054],"category_scores_gemma":[0.0001399249,0.0001493101,0.0002405949,0.00007836679,0.0003983504,0.0001522441,0.0003107669,0.0003696399,0.0003022167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002804895,"about_ca_system_score_gemma":0.0002994313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008305574,"about_ca_topic_score_gemma":0.001962309,"domain_scores_codex":[0.9999025,0.00000834957,0.00001070026,0.00003612899,0.00001993065,0.00002239615],"domain_scores_gemma":[0.9998075,0.00001586816,0.00006840628,0.00001984227,0.00001355427,0.00007479004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000127791,0.00002607899,0.000389593,0.00004243029,0.000004713024,0.00009790151,0.000009251973,0.00006879579,0.997588,0.00009918164,0.00007646263,0.001469704],"study_design_scores_gemma":[0.0000494097,0.0004464863,0.0217158,0.00003250042,0.00002420664,0.0005480507,0.00004346727,0.001506456,0.9704409,0.0001363125,0.005041806,0.00001470018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953963,0.0007091237,0.001516443,0.0001093295,0.00004886443,0.00003537006,0.0007446997,0.0001925798,0.001247294],"genre_scores_gemma":[0.9928442,0.000479726,0.002556625,0.00006270699,0.000009459677,0.00005131548,0.0006655733,0.00005645424,0.00327384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001573054,"threshold_uncertainty_score":0.005262375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04318521805413236,"score_gpt":0.3534587506719208,"score_spread":0.3102735326177885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}