{"id":"W4399654850","doi":"10.1016/j.chempr.2024.05.007","title":"Metal ions turn on a stereoselective nonenzymatic reduction of keto acids by the coenzyme NADH","year":2024,"lang":"en","type":"article","venue":"Chem","topic":"Origins and Evolution of Life","field":"Physics and Astronomy","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"H2020 European Research Council; Horizon 2020; European Research Council; Université de Strasbourg; Volkswagen Foundation; Horizon 2020 Framework Programme; Deutsche Forschungsgemeinschaft; European Commission; Equipex; VWR Foundation","keywords":"Stereoselectivity; Cofactor; Chemistry; Metal ions in aqueous solution; Metal; Turn (biochemistry); Coenzyme A; Reduction (mathematics); Combinatorial chemistry; Biochemistry; Stereochemistry; Organic chemistry; Catalysis; Reductase; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007727506,0.00008727439,0.0001057412,0.0000288767,0.0000711004,0.00003051607,0.00007700845,0.00002063363,0.0003070791],"category_scores_gemma":[0.000002616645,0.00005896382,0.00009282433,0.0001666563,0.00004742813,0.00007068959,0.00001556785,0.0001371249,0.00007315216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003164339,"about_ca_system_score_gemma":0.0000438025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006492488,"about_ca_topic_score_gemma":6.850976e-7,"domain_scores_codex":[0.999495,0.00001654379,0.0001287032,0.0001318512,0.0001116497,0.0001162316],"domain_scores_gemma":[0.9997248,0.00003542278,0.00003907731,0.0001382282,0.00002963992,0.00003280698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005447266,0.0006309878,0.0006034668,0.0001324062,0.00103565,0.000001194162,0.004470498,0.00006888824,0.1438352,0.1522331,0.6787622,0.01817191],"study_design_scores_gemma":[0.0006071995,0.000295145,0.0008196432,0.0002006586,0.0002227638,0.000008583179,0.0029973,0.002057966,0.728383,0.0105166,0.253505,0.0003861934],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767041,0.000333177,0.001641074,0.001079915,0.0005462871,0.0001794067,0.0001614186,0.00004662029,0.01930805],"genre_scores_gemma":[0.9964518,0.00000174199,0.00004736391,0.00001692174,0.0003626267,0.00002263707,0.00002418092,0.00001074147,0.003061977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5845478,"threshold_uncertainty_score":0.3362301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01123307763963101,"score_gpt":0.2544106828498173,"score_spread":0.2431776052101863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}