{"id":"W4399654863","doi":"10.1016/j.isci.2024.110241","title":"The E3 ubiquitin ligase Nedd4L preserves skeletal muscle stem cell quiescence by inhibiting their activation","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of Manitoba; McGill University; Research Manitoba; Jewish General Hospital","funders":"Lady Davis Institute for Medical Research; Natural Sciences and Engineering Research Council of Canada; Genome Canada; Canadian Institutes of Health Research; Terry Fox Research Institute; Warren Y. Soper Charitable Trust; McGill University","keywords":"Ubiquitin ligase; Ubiquitin; Cell biology; Skeletal muscle; Stem cell; DNA ligase; Chemistry; Ubiquitin-Protein Ligases; Biochemistry; Biology; Anatomy; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001784797,0.0002773775,0.0002822328,0.0003241604,0.0001268605,0.000397308,0.0002690802,0.0002244461,0.001286562],"category_scores_gemma":[0.00009208483,0.0001879579,0.0001850171,0.0001260026,0.0002723612,0.0002216318,0.0002032655,0.0004377732,0.0003045633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003614327,"about_ca_system_score_gemma":0.0002898396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003528732,"about_ca_topic_score_gemma":0.0008417652,"domain_scores_codex":[0.9998602,0.00001880976,0.00001657649,0.000034493,0.00003730397,0.00003257588],"domain_scores_gemma":[0.9999005,0.000009246874,0.00003487684,0.00001076011,0.000009972818,0.0000346361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006129252,0.00001169662,0.0001640356,0.00002085337,0.00000380434,0.00002204022,0.000004340643,0.00002684609,0.9984395,0.0001297156,0.00002061842,0.001095295],"study_design_scores_gemma":[0.00001180538,0.00009633678,0.001584656,0.000002603721,0.000007699365,0.00007901747,0.000008130831,0.0003703381,0.9958082,0.0000384481,0.001991039,0.000001649371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892985,0.001841695,0.005777734,0.0001210402,0.00004132252,0.00002107718,0.0005450333,0.0002062583,0.002147454],"genre_scores_gemma":[0.9897959,0.0006016333,0.003053694,0.00005714409,0.000007673677,0.00002877592,0.0006371715,0.00004455856,0.005773505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001286562,"threshold_uncertainty_score":0.004303992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0133416017094831,"score_gpt":0.2384382633616408,"score_spread":0.2250966616521577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}