{"id":"W4399655685","doi":"10.1016/s2468-1253(24)00119-5","title":"Nanoliposomal irinotecan and fluorouracil plus leucovorin versus fluorouracil plus leucovorin in patients with cholangiocarcinoma and gallbladder carcinoma previously treated with gemcitabine-based therapies (AIO NALIRICC): a multicentre, open-label, randomised, phase 2 trial","year":2024,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Fluorouracil; Gemcitabine; Medicine; Irinotecan; Internal medicine; Gallbladder; Gastroenterology; Oncology; Chemotherapy; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002268522,0.00117482,0.002083354,0.0003742604,0.0003209408,0.001000729,0.0005740996,0.001357924,0.00438652],"category_scores_gemma":[0.001618038,0.0005389636,0.001854705,0.0003224546,0.0007754412,0.0009043295,0.0004175082,0.001957882,0.0007233123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009778702,"about_ca_system_score_gemma":0.001088795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005814498,"about_ca_topic_score_gemma":0.001432683,"domain_scores_codex":[0.9993187,0.0003793152,0.00005079832,0.0001194127,0.00004791728,0.00008394442],"domain_scores_gemma":[0.9992655,0.000188575,0.0002317665,0.00004740993,0.00004594365,0.0002207031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9794247,0.00667157,0.0005632849,0.0005237197,0.0006673721,0.00002572281,0.00004662715,0.0002509209,0.002531748,0.0000620508,0.0003208311,0.008911365],"study_design_scores_gemma":[0.9192008,0.07828648,0.001113802,0.00002769699,0.0003035178,0.00002241311,0.00001311145,0.0002559632,0.0002997655,0.00007233532,0.0003959528,0.000008044703],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881628,0.004033838,0.0003927801,0.0005830115,0.0004333332,0.004600046,0.000466621,0.00004602611,0.001281413],"genre_scores_gemma":[0.98873,0.001883922,0.001041942,0.0007506893,0.0003366643,0.004816093,0.0004938857,0.000009491773,0.001937316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00438652,"threshold_uncertainty_score":0.01467437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03669692407486688,"score_gpt":0.2929383990949566,"score_spread":0.2562414750200896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}