{"id":"W4399655685","doi":"10.1016/s2468-1253(24)00119-5","title":"Nanoliposomal irinotecan and fluorouracil plus leucovorin versus fluorouracil plus leucovorin in patients with cholangiocarcinoma and gallbladder carcinoma previously treated with gemcitabine-based therapies (AIO NALIRICC): a multicentre, open-label, randomised, phase 2 trial","year":2024,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Fluorouracil; Gemcitabine; Medicine; Irinotecan; Internal medicine; Gallbladder; Gastroenterology; Oncology; Chemotherapy; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005502612,0.0009897177,0.002412877,0.000442674,0.0003326607,0.0002233668,0.0005413262,0.0003156986,0.0000465253],"category_scores_gemma":[0.00005961637,0.0006533129,0.0001460854,0.0004556417,0.0009987616,0.0003404955,0.0003674522,0.001006669,0.000009395259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005543332,"about_ca_system_score_gemma":0.0005304629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001406997,"about_ca_topic_score_gemma":0.006385652,"domain_scores_codex":[0.994698,0.0007396622,0.0009066968,0.001524652,0.0004866193,0.001644297],"domain_scores_gemma":[0.9976667,0.0005086035,0.0003141094,0.0009031824,0.000246067,0.0003613596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4604668,0.0006463407,0.5329238,0.0001941855,0.001067792,0.0008309043,0.00123142,0.000006954511,0.00009118958,0.00001354558,0.0004057243,0.002121349],"study_design_scores_gemma":[0.6837088,0.02334498,0.2867283,0.0002443204,0.001186392,0.0004556558,0.000339398,0.002581042,0.0000836937,0.000004727812,0.0008525916,0.0004701712],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850278,0.006174132,0.00009691225,0.002882727,0.0004871292,0.00492125,0.0000972473,0.0001838131,0.0001289385],"genre_scores_gemma":[0.9959769,0.0002422725,0.0004492639,0.001344837,0.0004207577,0.001155938,0.0001721148,0.0001275838,0.0001103115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2461955,"threshold_uncertainty_score":0.9995918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03669692407486688,"score_gpt":0.2929383990949566,"score_spread":0.2562414750200896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}