{"id":"W4399659897","doi":"10.1139/cjm-2023-0235","title":"The limit to evolutionary rescue depends on ploidy in yeast exposed to nystatin","year":2024,"lang":"en","type":"article","venue":"Canadian Journal of Microbiology","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Biotechnology and Biological Sciences Research Council; University of British Columbia Graduate School; Natural Sciences and Engineering Research Council of Canada","keywords":"Ploidy; Biology; Nystatin; Adaptation (eye); Yeast; Genetics; Saccharomyces cerevisiae; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002632155,0.0002949892,0.0003969254,0.0002400647,0.0001759674,0.0003773819,0.0002999805,0.0003431619,0.001296256],"category_scores_gemma":[0.0007755532,0.0002070785,0.0002044402,0.0001498924,0.0003026255,0.0003750601,0.0007704059,0.0007902081,0.0003411843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003082552,"about_ca_system_score_gemma":0.0001959209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005660504,"about_ca_topic_score_gemma":0.0005125395,"domain_scores_codex":[0.9997781,0.0000395103,0.00003003894,0.00006526322,0.00005685024,0.00003025511],"domain_scores_gemma":[0.9992835,0.0002672492,0.0001402366,0.0001225294,0.00007503876,0.0001114573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000135372,0.00001395222,0.0008043532,0.00002372991,0.000005744977,0.00006664179,0.00003606191,0.0002247051,0.9969938,0.00007134357,0.00001802433,0.001606302],"study_design_scores_gemma":[0.0000471118,0.001096532,0.0472036,0.00002852335,0.00002705671,0.00092578,0.0002866615,0.005594851,0.9416276,0.0005469572,0.002582399,0.00003285363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952047,0.0006921,0.002833865,0.000105367,0.00001199431,0.00001554541,0.0002112379,0.00003983672,0.0008854157],"genre_scores_gemma":[0.996439,0.0003601671,0.00136819,0.00006183607,0.000004019618,0.00002762189,0.0004018371,0.00004325211,0.001294088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001296256,"threshold_uncertainty_score":0.004336417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007622490959428851,"score_gpt":0.2265938029437697,"score_spread":0.2189713119843408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}