{"id":"W4399660826","doi":"10.1016/j.isci.2024.110263","title":"Machine learning on longitudinal multi-modal data enables the understanding and prognosis of Alzheimer’s disease progression","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; National Key Research and Development Program of China; National Health and Medical Research Council; Genentech; National Institutes of Health; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Austin Health; IXICO; Natural Science Foundation of Xinjiang; H. Lundbeck A/S; Servier; Eisai; National Natural Science Foundation of China; University of Melbourne; National Institute on Aging; Commonwealth Scientific and Industrial Research Organisation; Northern California Institute for Research and Education; Natural Science Foundation of Xinjiang Province; University of Southern California; Pfizer; Biogen; BioClinica; Eli Lilly and Company; U.S. Department of Defense; Medical Research Council; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; State Government of Victoria; Novartis Pharmaceuticals Corporation; Dementia Collaborative Research Centres, Australia; Edith Cowan University; Yulgilbar Foundation; Bristol-Myers Squibb; Alzheimer's Drug Discovery Foundation; Science and Industry Endowment Fund; Alzheimer's Association","keywords":"Disease; Longitudinal data; Modal; Data science; Neuroscience; Alzheimer's disease; Cognitive science; Medicine; Computer science; Psychology; Internal medicine; Chemistry; Data mining","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004328745,0.000627281,0.000652806,0.001347049,0.000380408,0.001114121,0.000544448,0.000749744,0.0006494676],"category_scores_gemma":[0.01060371,0.0002207101,0.0008610964,0.0009324223,0.0003759846,0.001070632,0.0007075287,0.001425971,0.0003051272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005920719,"about_ca_system_score_gemma":0.0007878551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004804832,"about_ca_topic_score_gemma":0.005709114,"domain_scores_codex":[0.999168,0.0004456513,0.00005760942,0.0001897129,0.00008594935,0.00005294509],"domain_scores_gemma":[0.9954914,0.003131995,0.0005083136,0.0004261978,0.0003153736,0.0001267423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.0006565304,0.000701614,0.290248,0.0002221006,0.0007677943,0.0003271211,0.0002900845,0.4101223,0.004553024,0.005101173,0.004960239,0.28205],"study_design_scores_gemma":[0.000009819718,0.0001218696,0.01919385,0.00003727381,0.00004775903,0.00007487363,0.00004681831,0.9702638,0.0006988404,0.00863247,0.0008458764,0.00002663549],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.546133,0.003558666,0.4400789,0.003162573,0.0002086692,0.0001398428,0.003312165,0.001173676,0.00223258],"genre_scores_gemma":[0.9565569,0.000813112,0.03992001,0.0001773284,0.0001148584,0.00008904091,0.001621703,0.00002429257,0.0006826997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004804832,"threshold_uncertainty_score":0.02289283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.189435326542626,"score_gpt":0.4165649347674241,"score_spread":0.2271296082247981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}