{"id":"W4399662535","doi":"10.1200/jco.2024.42.16_suppl.2614","title":"Pharmacokinetic (PK) and pharmacodynamic (PD) findings from a phase 1b study of ATR inhibitor tuvusertib + anti-PD-L1 avelumab in patients with advanced unresectable solid tumors.","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"EMD Serono","keywords":"Medicine; Pharmacokinetics; Avelumab; Pharmacodynamics; Pharmacology; Solid tumor; Oncology; Internal medicine; Cancer; Pembrolizumab; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001178196,0.0008710178,0.001230811,0.0003354843,0.0002807535,0.000774403,0.0004908948,0.0007128562,0.001929172],"category_scores_gemma":[0.001040452,0.0005443738,0.0007716137,0.0003504871,0.0006016355,0.000603752,0.000217312,0.001831008,0.0005088802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008340008,"about_ca_system_score_gemma":0.0007079894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000570556,"about_ca_topic_score_gemma":0.001091985,"domain_scores_codex":[0.9995604,0.0002134704,0.00002116486,0.00009413445,0.00004939831,0.00006127929],"domain_scores_gemma":[0.9994111,0.0001298899,0.0001708461,0.00004979232,0.00002756194,0.0002108518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.40372,0.05658086,0.02949406,0.0007772085,0.001747477,0.000695157,0.0006167373,0.00649832,0.3463338,0.0003482509,0.004112203,0.149076],"study_design_scores_gemma":[0.1335662,0.7293995,0.08657029,0.00004248163,0.00125047,0.001899325,0.0001305459,0.005373752,0.0346142,0.0002801946,0.006794495,0.00007854008],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964387,0.001319349,0.0005675533,0.0001284872,0.00002372817,0.0003856928,0.0004084833,0.00005309075,0.00067482],"genre_scores_gemma":[0.9961235,0.0005908359,0.000897013,0.0002084237,0.0000528919,0.0003607107,0.0009176985,0.00002178223,0.0008271923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001929172,"threshold_uncertainty_score":0.006453693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03838526387735447,"score_gpt":0.4547933671809966,"score_spread":0.4164081033036421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}