{"id":"W4399662535","doi":"10.1200/jco.2024.42.16_suppl.2614","title":"Pharmacokinetic (PK) and pharmacodynamic (PD) findings from a phase 1b study of ATR inhibitor tuvusertib + anti-PD-L1 avelumab in patients with advanced unresectable solid tumors.","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"EMD Serono","keywords":"Medicine; Pharmacokinetics; Avelumab; Pharmacodynamics; Pharmacology; Solid tumor; Oncology; Internal medicine; Cancer; Pembrolizumab; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001116199,0.0002224405,0.00179033,0.0003003771,0.00003016806,0.00001641639,0.0001468862,0.0001547999,0.0002703053],"category_scores_gemma":[0.0002556898,0.0001561362,0.0001831229,0.0003341466,0.0001123966,0.0002088672,0.00006235877,0.001090707,0.000003017647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001667558,"about_ca_system_score_gemma":0.0007352361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008529334,"about_ca_topic_score_gemma":0.00008892248,"domain_scores_codex":[0.9964407,0.0002435289,0.002187984,0.0003501211,0.0004872819,0.0002903632],"domain_scores_gemma":[0.9976662,0.0008445597,0.0007685501,0.000151575,0.0002608391,0.0003082748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1431776,0.0667746,0.2779543,0.000418091,0.00323888,0.006262133,0.003885796,0.0002201712,0.05791389,0.00002800483,0.001111642,0.4390149],"study_design_scores_gemma":[0.3410904,0.1738183,0.4638716,0.002175909,0.001815392,0.0001581299,0.0009650722,0.004356585,0.005545187,0.0003403239,0.005367857,0.0004952832],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962891,0.0009867504,0.0000646849,0.0005742687,0.001316445,0.0006649503,0.00003068869,0.00001405886,0.00005906879],"genre_scores_gemma":[0.9979456,0.0005689682,0.000460617,0.0004233774,0.0004946618,0.00001001512,0.00000667426,0.00004073314,0.00004936569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4385197,"threshold_uncertainty_score":0.636705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03838526387735447,"score_gpt":0.4547933671809966,"score_spread":0.4164081033036421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}