{"id":"W4399663900","doi":"10.1093/braincomms/fcae185","title":"Impaired glymphatic system in genetic frontotemporal dementia: a GENFI study","year":2024,"lang":"en","type":"article","venue":"Brain Communications","topic":"Cerebrospinal fluid and hydrocephalus","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Western University; Occupational Cancer Research Centre; Health Sciences Centre; Montreal Neurological Institute and Hospital; University of Toronto; McGill University Health Centre; Sunnybrook Health Science Centre; Université Laval","funders":"Canadian Institutes of Health Research; Tau Consortium; Alzheimer Nederland; Medical Research Council; Medical Research Council Canada; Stockholms Läns Landsting; Weston Brain Institute; Alzheimerfonden; ZonMw; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Brain Foundation; Wellcome Trust; University College London; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fondation pour la Recherche sur Alzheimer; Ministero della Salute; Alzheimer's Society; Deutsche Forschungsgemeinschaft; Brain Research UK; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; National Science Foundation; Università degli Studi di Brescia; Ontario Brain Institute; Stichting Dioraphte; NIHR Cambridge Biomedical Research Centre; Else Kröner-Fresenius-Stiftung; University of Cambridge","keywords":"Frontotemporal dementia; Glymphatic system; Diffusion MRI; Dementia; Psychology; Medicine; Neuroscience; Pathology; Cerebrospinal fluid; Disease; Magnetic resonance imaging; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004515159,0.0007685598,0.0002955933,0.0009244063,0.0006397518,0.0004464428,0.0002912351,0.0004992099,0.002093925],"category_scores_gemma":[0.0009292118,0.0002272935,0.0003758323,0.0006031242,0.0005570591,0.0003117031,0.0003680566,0.000303289,0.0002505699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003280944,"about_ca_system_score_gemma":0.0002187139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005764295,"about_ca_topic_score_gemma":0.003957267,"domain_scores_codex":[0.9998516,0.00003574142,0.00001282997,0.00004773316,0.00002426045,0.00002767214],"domain_scores_gemma":[0.9996341,0.00009089592,0.0001315854,0.00003482966,0.0000443496,0.00006425491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001045663,0.0001783075,0.9876203,0.0000344007,0.0001848335,0.00341851,0.0006788681,0.00007400334,0.003752192,0.0001200012,0.0001325613,0.002760274],"study_design_scores_gemma":[0.00001989498,0.0002738229,0.9959956,0.000007571351,0.00008617789,0.002633742,0.0002193416,0.0001254941,0.0002782758,0.0000836944,0.0002702113,0.000006182976],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995383,0.0001109419,0.00004306937,0.00001359131,0.000002473071,0.000003830065,0.00008417741,0.000001761589,0.0002019018],"genre_scores_gemma":[0.9995885,0.00006068462,0.00005917916,0.00001483431,0.000005744651,0.000003354797,0.0001038222,0.0000015807,0.0001622924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005764295,"threshold_uncertainty_score":0.0114615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05125129098893973,"score_gpt":0.317974757963786,"score_spread":0.2667234669748463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}