{"id":"W4399672112","doi":"10.3390/pharmaceutics16060811","title":"Development of neffy, an Epinephrine Nasal Spray, for Severe Allergic Reactions","year":2024,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Allergic Rhinitis and Sensitization","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"ARS Pharmaceuticals","keywords":"Epinephrine; Medicine; Anaphylaxis; Pharmacodynamics; Nasal spray; Pharmacokinetics; Anesthesia; Pharmacology; Drug; Allergy; Nasal administration; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005789213,0.0003785832,0.0002426515,0.0003484786,0.0001543253,0.0002575824,0.0003797886,0.0005170326,0.001096772],"category_scores_gemma":[0.0003963524,0.0001475922,0.0004664533,0.00009744565,0.0001683308,0.0003355471,0.0002170662,0.0008512379,0.0003557323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002157317,"about_ca_system_score_gemma":0.0004647025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005751426,"about_ca_topic_score_gemma":0.001015677,"domain_scores_codex":[0.9997113,0.00004672843,0.00001549342,0.00004454115,0.0001454663,0.00003631684],"domain_scores_gemma":[0.9998719,0.00001874161,0.00002596438,0.000006862328,0.00004093217,0.00003571196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003533953,0.0009448666,0.0005948661,0.0006245565,0.00006069213,0.0005541943,0.0001125462,0.0005629034,0.8569892,0.001103535,0.001741436,0.1363579],"study_design_scores_gemma":[0.0007928091,0.02234652,0.009281881,0.0002619995,0.0001608614,0.00543468,0.00007048737,0.002757401,0.8240166,0.0003524013,0.1344616,0.00006266037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.814062,0.06821737,0.08375254,0.001935581,0.000931274,0.002787532,0.001172108,0.0006869292,0.02645468],"genre_scores_gemma":[0.9197661,0.03014678,0.03722717,0.001058742,0.0001406993,0.000636342,0.001073864,0.00006847933,0.009881877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001096772,"threshold_uncertainty_score":0.003669083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09728263884205623,"score_gpt":0.3901130493624235,"score_spread":0.2928304105203672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}