{"id":"W4399672112","doi":"10.3390/pharmaceutics16060811","title":"Development of neffy, an Epinephrine Nasal Spray, for Severe Allergic Reactions","year":2024,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Allergic Rhinitis and Sensitization","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"ARS Pharmaceuticals","keywords":"Epinephrine; Medicine; Anaphylaxis; Pharmacodynamics; Nasal spray; Pharmacokinetics; Anesthesia; Pharmacology; Drug; Allergy; Nasal administration; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001610729,0.0001119407,0.0001719293,0.00009122308,0.00007056581,0.00001638895,0.00004180932,0.00005590881,0.0002254016],"category_scores_gemma":[0.00002801497,0.00010177,0.00006138018,0.000147047,0.00002525402,0.00009407296,0.00002006078,0.0001247321,0.00002120615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005812042,"about_ca_system_score_gemma":0.0002211938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003173419,"about_ca_topic_score_gemma":0.00001030697,"domain_scores_codex":[0.9991339,0.00001442312,0.0003296377,0.0001803384,0.0001784776,0.0001631582],"domain_scores_gemma":[0.9995078,0.00005787351,0.00004642396,0.000122334,0.0001420149,0.0001235791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001277548,0.001385149,0.0007298376,0.004337921,0.001809719,0.0002875905,0.01182386,0.001153779,0.5450535,0.01985354,0.017986,0.3943015],"study_design_scores_gemma":[0.001273705,0.0001060883,0.0004937947,0.0001767295,0.0001429614,0.0002064543,0.0002574708,0.05554322,0.05007371,0.0001499174,0.8914111,0.0001648551],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9604816,0.001182915,0.02359894,0.002452576,0.001347841,0.001079471,0.00006091213,0.0003339282,0.009461827],"genre_scores_gemma":[0.9624153,0.0003276246,0.03461058,0.0003622752,0.0003323782,0.00002175829,0.0002664603,0.00003670507,0.001626906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8734251,"threshold_uncertainty_score":0.415006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09728263884205623,"score_gpt":0.3901130493624235,"score_spread":0.2928304105203672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}