{"id":"W4399679570","doi":"10.1002/bies.202400062","title":"Culture‐acquired genetic variation in human pluripotent stem cells: Twenty years on","year":2024,"lang":"en","type":"review","venue":"BioEssays","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Canadian Institutes of Health Research; UK Regenerative Medicine Platform","keywords":"Induced pluripotent stem cell; Human Induced Pluripotent Stem Cells; Biology; Phenotype; Neuroscience; Evolutionary biology; Genetics; Embryonic stem cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001474566,0.0007217285,0.001015294,0.001620956,0.0002428892,0.001287277,0.0008843737,0.001312206,0.002744783],"category_scores_gemma":[0.001576878,0.0002638414,0.0005094919,0.00175812,0.0008556752,0.001995885,0.001066782,0.002393217,0.001482437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000622412,"about_ca_system_score_gemma":0.0008874976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006847039,"about_ca_topic_score_gemma":0.001005413,"domain_scores_codex":[0.9995684,0.00008797651,0.00006702341,0.00007264478,0.0001683882,0.00003565981],"domain_scores_gemma":[0.9988775,0.0007091715,0.00008067452,0.00004518518,0.0002310402,0.00005637153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008774395,0.00003845911,0.000196153,0.01046957,0.00006388447,0.0002719121,0.0001252827,0.0002449059,0.002739782,0.008841911,0.03299406,0.9439264],"study_design_scores_gemma":[0.000006910481,0.00007435513,0.0004250754,0.002223123,0.00005860044,0.000861378,0.00005798752,0.00004257657,0.0007914131,0.002658943,0.9927828,0.00001674445],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001275984,0.9977708,0.0001753364,0.0007500466,0.0005175067,0.000002844341,0.00001520689,0.000008566956,0.0006320835],"genre_scores_gemma":[0.0007923276,0.9970373,0.0002001181,0.000748035,0.0004718232,0.00000537154,0.00003459026,0.000003480104,0.0007069684],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002744783,"threshold_uncertainty_score":0.009182274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03922935464074685,"score_gpt":0.3236622699743655,"score_spread":0.2844329153336187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}