{"id":"W4399679570","doi":"10.1002/bies.202400062","title":"Culture‐acquired genetic variation in human pluripotent stem cells: Twenty years on","year":2024,"lang":"en","type":"review","venue":"BioEssays","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Canadian Institutes of Health Research; UK Regenerative Medicine Platform","keywords":"Induced pluripotent stem cell; Human Induced Pluripotent Stem Cells; Biology; Phenotype; Neuroscience; Evolutionary biology; Genetics; Embryonic stem cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003938122,0.0005641733,0.0008315819,0.0003355212,0.0000656214,0.0001176015,0.0006621253,0.0008252594,0.00003282324],"category_scores_gemma":[0.00001175789,0.0004700183,0.0005047721,0.0003741717,0.00007502594,0.00000338062,0.0003961393,0.0003648032,0.0005639091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002234251,"about_ca_system_score_gemma":0.0002345049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003399373,"about_ca_topic_score_gemma":0.00002155691,"domain_scores_codex":[0.9967238,0.0003750988,0.000698168,0.001159669,0.0004828914,0.0005603427],"domain_scores_gemma":[0.9987165,0.00001479321,0.0002132251,0.0008524084,0.00005104939,0.0001519699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008360815,0.001009427,0.00001174276,0.03620477,0.001313647,0.0009873396,0.0003326469,0.0001159671,0.1061392,0.0005252017,0.03656098,0.8167154],"study_design_scores_gemma":[0.0002925382,0.000289237,0.0000248188,0.003087348,0.0002677482,0.00001817977,0.00001020108,0.00001491014,0.001230552,0.00003360645,0.9941753,0.0005556333],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007201393,0.9959627,0.00004425479,0.0000152342,0.0006798675,0.001172893,0.0001814855,0.00003841846,0.00118504],"genre_scores_gemma":[0.001234505,0.9896275,0.00008082616,0.00003127391,0.0005483762,0.0002217134,0.0004690437,0.0001315037,0.007655307],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9576142,"threshold_uncertainty_score":0.9997752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03922935464074685,"score_gpt":0.3236622699743655,"score_spread":0.2844329153336187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}