{"id":"W4399681171","doi":"10.1186/s40345-024-00334-x","title":"Pilot study of circulating cell-free mitochondrial DNA in relation to brain structure in youth bipolar disorder","year":2024,"lang":"en","type":"article","venue":"International Journal of Bipolar Disorders","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Heart and Stroke Foundation; University of Toronto; Sunnybrook Health Science Centre; Centre for Addiction and Mental Health","funders":"National Institute of Mental Health; University of Toronto; Canadian Institutes of Health Research; Centre for Addiction and Mental Health Foundation; Fondation Brain Canada","keywords":"Bipolar disorder; Neurology; Brain Cell; Mitochondrial DNA; Psychopharmacology; Mitochondrion; Medicine; Neuroscience; Psychiatry; Psychology; Biology; Lithium (medication); Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000314705,0.000242836,0.0004164637,0.001494461,0.000029617,0.00005329838,0.0003789489,0.00007635431,0.00007982776],"category_scores_gemma":[0.0003436402,0.0002133355,0.0001550469,0.0006813012,0.00003454457,0.0002950308,0.000101777,0.0005823133,0.000004770887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002726013,"about_ca_system_score_gemma":0.0002015126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001891041,"about_ca_topic_score_gemma":0.01260966,"domain_scores_codex":[0.9973778,0.0001436316,0.001003412,0.0003047195,0.0009316172,0.0002388558],"domain_scores_gemma":[0.9990411,0.0001699571,0.0002427614,0.0002494063,0.0001803813,0.0001163847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001212295,0.004112482,0.911904,0.00008680209,0.0005622719,0.000119696,0.01626404,0.002552078,0.01736104,0.000140139,0.0001032647,0.04558189],"study_design_scores_gemma":[0.01527359,0.005624327,0.9635289,0.0009060556,0.00026774,0.0001072491,0.006340537,0.0007973079,0.0004201568,0.001478214,0.004894614,0.000361261],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761848,0.01936123,0.0005221671,0.00179147,0.001309328,0.0006299053,0.00008180578,0.00001746589,0.0001017616],"genre_scores_gemma":[0.998798,0.0003675999,0.0004433999,0.00006535026,0.0002037569,0.000006067214,0.00003800284,0.00004463271,0.00003317502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05162494,"threshold_uncertainty_score":0.869957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01350168355955936,"score_gpt":0.2759494416054569,"score_spread":0.2624477580458975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}