{"id":"W4399688056","doi":"10.3389/fcell.2024.1368711","title":"Defining melanoma combination therapies that provide senolytic sensitivity in human melanoma cells","year":2024,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Institute of Cancer Research; Fonds de Recherche du Québec - Santé; Université de Montréal","keywords":"Melanoma; Cancer research; DNA damage; Senescence; Carboplatin; Biology; Targeted therapy; Context (archaeology); Cancer; Cancer cell; Programmed cell death; Apoptosis; Chemotherapy; Cell biology; Cisplatin; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002746774,0.000366929,0.0004472008,0.0003786267,0.0001549655,0.0003393421,0.0002397982,0.0003359035,0.002292373],"category_scores_gemma":[0.0001418219,0.0001823369,0.000260832,0.0002416209,0.0001238973,0.0001990637,0.0002297322,0.0005371711,0.0005053174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002583461,"about_ca_system_score_gemma":0.0002078593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004296408,"about_ca_topic_score_gemma":0.001199493,"domain_scores_codex":[0.999791,0.00005600867,0.00001790739,0.0000420604,0.00006036992,0.00003264142],"domain_scores_gemma":[0.9999126,0.00001856367,0.00001686641,0.0000190298,0.00001631755,0.00001669051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003642658,0.0002615969,0.0003003459,0.00008600617,0.00001676157,0.00006362949,0.00003769319,0.0003839589,0.9889646,0.0001945089,0.0002832443,0.009043432],"study_design_scores_gemma":[0.0001139217,0.003039662,0.002377702,0.0000116641,0.00005041063,0.0005911912,0.00002183564,0.001367209,0.9818871,0.00005825915,0.01047412,0.000006977813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793214,0.006643187,0.006349619,0.000190052,0.00006486389,0.000434643,0.0006405006,0.0001547515,0.006200983],"genre_scores_gemma":[0.9845341,0.00282058,0.007073073,0.0001022267,0.00002350722,0.0003599452,0.0007111867,0.00004139376,0.004333956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002292373,"threshold_uncertainty_score":0.007668734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0106701946458684,"score_gpt":0.2477518031028674,"score_spread":0.237081608456999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}