{"id":"W4399693793","doi":"10.1016/j.radonc.2024.110380","title":"Radiation enhancement using focussed ultrasound-stimulated microbubbles for head and neck cancer: A phase 1 clinical trial","year":2024,"lang":"en","type":"article","venue":"Radiotherapy and Oncology","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Terry Fox Research Institute; Sunnybrook Research Institute; Varian Medical Systems","keywords":"Microbubbles; Medicine; Ultrasound; Head and neck; Head and neck cancer; Radiation therapy; Magnetic resonance imaging; Radiology; Nuclear medicine; Cancer research; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001953523,0.001495442,0.001669301,0.0003640602,0.0003321733,0.0008468109,0.0007919755,0.001558046,0.002671197],"category_scores_gemma":[0.0008660429,0.0004221552,0.0009406037,0.0003504107,0.0008339217,0.0006529898,0.0003108072,0.001939287,0.0004972917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007232874,"about_ca_system_score_gemma":0.001832298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000561748,"about_ca_topic_score_gemma":0.001353704,"domain_scores_codex":[0.9996046,0.0001889056,0.00001855948,0.00006033675,0.00004818905,0.0000793838],"domain_scores_gemma":[0.9995425,0.00009697962,0.0001312679,0.00004342789,0.00003608504,0.0001496916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6997783,0.0848809,0.004329788,0.002423217,0.001068821,0.0004525932,0.0005065851,0.002884836,0.07027251,0.0004211642,0.004966613,0.1280147],"study_design_scores_gemma":[0.4846774,0.4989737,0.004709388,0.00007209098,0.0003526676,0.0002872975,0.00004284309,0.0008452914,0.006954849,0.0002082826,0.002845167,0.00003093332],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889463,0.003831607,0.0006933308,0.0003974656,0.000120383,0.00423765,0.00065937,0.00007560201,0.001038342],"genre_scores_gemma":[0.9782633,0.005372492,0.002405043,0.001219098,0.0003193838,0.007951554,0.001662272,0.00003351964,0.00277328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002671197,"threshold_uncertainty_score":0.01033139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05013795792559933,"score_gpt":0.4023475700030114,"score_spread":0.352209612077412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}