{"id":"W4399694752","doi":"10.1159/000538959","title":"Efficacy and Safety of Hydrocortisone, Ascorbic Acid, and Thiamine Combination Therapy for the Management of Sepsis and Septic Shock: A Systematic Review and Meta-Analysis of Randomised Controlled Trials","year":2024,"lang":"en","type":"review","venue":"International Archives of Allergy and Immunology","topic":"Vitamin C and Antioxidants Research","field":"Nursing","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Queen's University; Public Health Ontario; University of British Columbia; University of Toronto; St. Michael's Hospital","funders":"","keywords":"Ascorbic acid; Septic shock; Medicine; Sepsis; Thiamine; Hydrocortisone; Meta-analysis; Randomized controlled trial; Shock (circulatory); Intensive care medicine; Clinical trial; Internal medicine; Gastroenterology; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01670036,0.002625781,0.02270008,0.007404297,0.0006501625,0.003504945,0.002211474,0.00212009,0.003300662],"category_scores_gemma":[0.03517497,0.001507732,0.0281376,0.007293146,0.0009057304,0.001822922,0.001378925,0.001570584,0.0002767531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003083676,"about_ca_system_score_gemma":0.005877242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005389072,"about_ca_topic_score_gemma":0.01257511,"domain_scores_codex":[0.9867138,0.006233139,0.004197372,0.001023282,0.001569792,0.0002625383],"domain_scores_gemma":[0.9775202,0.01633378,0.00402897,0.0004610347,0.001403621,0.0002523543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001426551,0.00002990255,0.001270023,0.7340223,0.2458065,0.00007451008,0.00008411088,0.0002758914,0.0002322985,0.0001115422,0.0004621629,0.01620422],"study_design_scores_gemma":[0.0009520061,0.0004018954,0.002513047,0.1070394,0.8854012,0.000126639,0.00006460482,0.0001714355,0.0001903381,0.0002328707,0.002872762,0.0000337477],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001975764,0.9968433,0.0002511526,0.0001571284,0.0001003379,0.000281573,0.0002383325,0.00001153215,0.000140903],"genre_scores_gemma":[0.05562535,0.9399468,0.001875637,0.0006810214,0.0001997166,0.001105148,0.0003900138,0.00001761843,0.0001586839],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02270008,"threshold_uncertainty_score":0.08832109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05992919701710765,"score_gpt":0.3771672495240759,"score_spread":0.3172380525069683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}