{"id":"W4399701489","doi":"10.1007/s00044-024-03256-6","title":"N-Benzyl, N-phenethyl and N-benzyloxybenzamide derivatives inhibit amyloid-beta (Aβ42) aggregation and mitigate Aβ42-induced neurotoxicity","year":2024,"lang":"en","type":"article","venue":"Medicinal Chemistry Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Chemistry; Cytotoxicity; Thioflavin; Neurotoxicity; Pentamer; Amyloid beta; Benzamide; Viability assay; Linker; Biophysics; Synucleinopathies; Lead compound; Biochemistry; Stereochemistry; Cell; In vitro; Alpha-synuclein; Alzheimer's disease; Toxicity; Parkinson's disease; Peptide; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001107657,0.0003757687,0.0004761591,0.0002571989,0.000377392,0.0002147023,0.0001687302,0.000223881,0.0003534432],"category_scores_gemma":[0.0006087286,0.0003049147,0.00009417596,0.000760337,0.0009412362,0.0002430483,0.0002886719,0.001335134,0.0000580163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001950496,"about_ca_system_score_gemma":0.0006712308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000242849,"about_ca_topic_score_gemma":0.00001044422,"domain_scores_codex":[0.9956663,0.000224425,0.0004049673,0.001002075,0.001739144,0.000963091],"domain_scores_gemma":[0.9971896,0.000636611,0.00004873613,0.0004724169,0.0003594565,0.001293121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001082232,0.0005606837,0.0352664,0.004864156,0.003268948,0.005236202,0.00120527,6.747111e-7,0.9049547,0.0002293199,0.002178804,0.04115267],"study_design_scores_gemma":[0.003064838,0.00101835,0.03489325,0.002051381,0.0003196799,0.0006857474,0.001057307,0.001414042,0.9526109,0.001242947,0.001245701,0.0003959298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9659656,0.02488467,0.000009037122,0.003750224,0.00004585065,0.0009157541,0.00003756215,0.0001379751,0.00425336],"genre_scores_gemma":[0.9966354,0.001738594,0.00006389064,0.0001112593,0.0004879458,0.0001838741,0.0001074991,0.00006508088,0.0006065062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04765617,"threshold_uncertainty_score":0.9999403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07374711448283168,"score_gpt":0.3866373197951053,"score_spread":0.3128902053122737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}