{"id":"W4399703344","doi":"10.1016/s1470-2045(24)00282-1","title":"Bortezomib, thalidomide, and dexamethasone with or without daratumumab and followed by daratumumab maintenance or observation in transplant-eligible newly diagnosed multiple myeloma: long-term follow-up of the CASSIOPEIA randomised controlled phase 3 trial","year":2024,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotel Dieu Hospital","funders":"Adaptive Biotechnologies; Celgene; National Cancer Institute; Yale University; Sanofi; Amgen; Pfizer; Bristol-Myers Squibb; GlaxoSmithKline","keywords":"Daratumumab; Medicine; Bortezomib; Multiple myeloma; Thalidomide; Internal medicine; Oncology; Regimen; Dexamethasone; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001294985,0.0003705458,0.001883943,0.0001232067,0.0001863134,0.00006629706,0.0002409004,0.0002062646,0.00005124391],"category_scores_gemma":[0.001051742,0.0001520823,0.0001420259,0.0004596529,0.0004519856,0.000152017,0.00006086949,0.0005065661,0.000002251417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001787772,"about_ca_system_score_gemma":0.0006635151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005026074,"about_ca_topic_score_gemma":0.008249467,"domain_scores_codex":[0.9969811,0.0007921305,0.0006711924,0.0005378831,0.0004007021,0.0006170209],"domain_scores_gemma":[0.9955883,0.00338914,0.0002375113,0.0005024922,0.0001010811,0.0001814449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9247387,0.0006937059,0.0543547,0.0002848196,0.000766404,0.00135519,0.001233898,0.000002128327,0.008326411,0.00002447208,0.001271336,0.006948215],"study_design_scores_gemma":[0.9591557,0.005008695,0.02702344,0.0007041636,0.0007142617,0.0003635456,0.0001757694,0.003798257,0.002034151,0.00001722243,0.0008027393,0.0002020009],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869073,0.001988065,0.0002537804,0.002638931,0.0003385689,0.007400685,0.0001613883,0.00005414283,0.0002571335],"genre_scores_gemma":[0.9943497,0.00158835,0.0004895514,0.0002365358,0.0001746017,0.001201887,0.00008595151,0.00004597001,0.001827449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03441704,"threshold_uncertainty_score":0.6201734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0623832820278561,"score_gpt":0.3682277431909751,"score_spread":0.305844461163119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}