{"id":"W4399703344","doi":"10.1016/s1470-2045(24)00282-1","title":"Bortezomib, thalidomide, and dexamethasone with or without daratumumab and followed by daratumumab maintenance or observation in transplant-eligible newly diagnosed multiple myeloma: long-term follow-up of the CASSIOPEIA randomised controlled phase 3 trial","year":2024,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotel Dieu Hospital","funders":"Adaptive Biotechnologies; Celgene; National Cancer Institute; Yale University; Sanofi; Amgen; Pfizer; Bristol-Myers Squibb; GlaxoSmithKline","keywords":"Daratumumab; Medicine; Bortezomib; Multiple myeloma; Thalidomide; Internal medicine; Oncology; Regimen; Dexamethasone; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00234991,0.001734251,0.003953753,0.0002903086,0.0006361318,0.001835671,0.001026916,0.001851176,0.004750553],"category_scores_gemma":[0.00228822,0.0006544646,0.004714584,0.0004916785,0.001554642,0.001281731,0.0006343141,0.004923517,0.0009077642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001654731,"about_ca_system_score_gemma":0.001660696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003871138,"about_ca_topic_score_gemma":0.007632037,"domain_scores_codex":[0.9989964,0.0005058243,0.00005398635,0.0001973936,0.00005500548,0.000191328],"domain_scores_gemma":[0.9985623,0.000417516,0.0003569679,0.0001599645,0.00006823565,0.0004350589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9918257,0.0008409182,0.0004838854,0.0002545294,0.001628135,0.00001978255,0.00002310873,0.0001946713,0.0006504045,0.00005537043,0.0004320491,0.003591531],"study_design_scores_gemma":[0.9770718,0.01762213,0.002844005,0.00004408167,0.00151499,0.00003100811,0.00002280432,0.0001571102,0.0001552554,0.0001573056,0.000365518,0.00001390779],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843898,0.01001054,0.0003588198,0.0009708571,0.0008777611,0.0007669897,0.001017423,0.00007000841,0.00153774],"genre_scores_gemma":[0.9899042,0.0035133,0.0005714116,0.001056556,0.0005113311,0.0008178712,0.001261918,0.00002389152,0.002339462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004750553,"threshold_uncertainty_score":0.01589215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0623832820278561,"score_gpt":0.3682277431909751,"score_spread":0.305844461163119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}