{"id":"W4399705658","doi":"10.1186/s12014-024-09492-7","title":"Glial fibrillary acidic protein, neurofilament light, matrix metalloprotease 3 and fatty acid binding protein 4 as non-invasive brain tumor biomarkers","year":2024,"lang":"en","type":"article","venue":"Clinical Proteomics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; University Health Network; Princess Margaret Cancer Centre; Public Health Ontario","funders":"National Cancer Institute; Canadian Cancer Society Research Institute; Northwestern University","keywords":"Glial fibrillary acidic protein; Fatty acid-binding protein; Matrix metalloproteinase; Pathology; GFAP stain; Metalloproteinase; Neurofilament; MMP3; Medicine; Cancer research; Chemistry; Biochemistry; Immunohistochemistry; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001162312,0.0007759805,0.0003620887,0.00120701,0.0001467402,0.0007611847,0.0004968873,0.0005133626,0.0007950125],"category_scores_gemma":[0.001882386,0.0001292052,0.0002758803,0.0007268878,0.0003752044,0.000477496,0.0003096664,0.000505545,0.0002802008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004294205,"about_ca_system_score_gemma":0.0004984216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009457736,"about_ca_topic_score_gemma":0.001366766,"domain_scores_codex":[0.9995512,0.0001903048,0.00002911646,0.00007300502,0.0001059878,0.00005048175],"domain_scores_gemma":[0.9989405,0.0004013949,0.0003387652,0.00003859877,0.0001654636,0.0001152793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003515798,0.0002910396,0.7965569,0.0006568411,0.0003402565,0.001078372,0.0001442796,0.001174167,0.07879174,0.0005618586,0.0009844389,0.1159043],"study_design_scores_gemma":[0.0002342912,0.003525592,0.8551912,0.0002633498,0.0008426912,0.007895075,0.0003557452,0.009548542,0.1085749,0.003541855,0.009942463,0.00008417325],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9515812,0.03709036,0.008217477,0.0005347949,0.00009978972,0.0001247613,0.0005550493,0.00009607699,0.001700414],"genre_scores_gemma":[0.9832354,0.004273743,0.01072336,0.0001748645,0.00007741244,0.0001293407,0.0004345052,0.00001021755,0.0009411974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00120701,"threshold_uncertainty_score":0.006146908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0250764572221372,"score_gpt":0.3310626305752863,"score_spread":0.3059861733531491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}