{"id":"W4399721908","doi":"10.1016/j.prp.2024.155401","title":"A comprehensive review of the PTEN/PI3K/Akt axis in multiple myeloma: From molecular interactions to potential therapeutic targets","year":2024,"lang":"en","type":"review","venue":"Pathology - Research and Practice","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"PTEN; PI3K/AKT/mTOR pathway; Protein kinase B; Tensin; Cancer research; RPTOR; MAPK/ERK pathway; Biology; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001563123,0.000378605,0.0009293006,0.0002211146,0.0001279151,0.00004836982,0.000661389,0.000396582,0.00007377133],"category_scores_gemma":[0.003543864,0.0002511108,0.0003229417,0.0006140499,0.000380411,0.00001453945,0.0009476728,0.001495447,0.0000698073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008024494,"about_ca_system_score_gemma":0.000542983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001535026,"about_ca_topic_score_gemma":0.00005870501,"domain_scores_codex":[0.9939361,0.003539171,0.0006511949,0.0009376149,0.0004242253,0.0005117484],"domain_scores_gemma":[0.9968154,0.001253239,0.0002831496,0.0009618898,0.000546877,0.0001394693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007115075,0.0005716457,0.00002013564,0.05553005,0.001804292,0.001358075,0.0003845305,0.000007427278,0.08451547,0.00008971643,0.01364563,0.8413615],"study_design_scores_gemma":[0.0001945218,0.0002889091,0.00001109771,0.01174132,0.0004954649,0.0004444438,0.00009017547,0.000004971917,0.0007705177,0.0001617638,0.985549,0.0002478063],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002674096,0.9951498,0.0002073017,0.00154469,0.0006400422,0.001441484,0.000373442,0.000009090537,0.0003667253],"genre_scores_gemma":[0.001683224,0.9954364,0.0006510924,0.001017431,0.0002487989,0.0004533267,0.0002289067,0.00006743374,0.0002134276],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9719034,"threshold_uncertainty_score":0.9999941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1266186374861914,"score_gpt":0.4643819073895216,"score_spread":0.3377632699033303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}