{"id":"W4399724308","doi":"10.1101/2024.06.14.598870","title":"THE CELLS ARE ALL-RIGHT: Regulation of the <i>Lefty</i> genes by separate enhancers in mouse embryonic stem cells","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Embryonic stem cell; Enhancer; Cell biology; Gene; Biology; Stem cell; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001461056,0.0002797465,0.0002490199,0.0002032531,0.0001522493,0.0004526145,0.0002916163,0.0002731817,0.001835935],"category_scores_gemma":[0.000128528,0.0002496311,0.0002846319,0.000119249,0.0003963556,0.0002606351,0.0004844696,0.0007738085,0.0006896777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003343041,"about_ca_system_score_gemma":0.0002159683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005279527,"about_ca_topic_score_gemma":0.0009393458,"domain_scores_codex":[0.9997506,0.00002221637,0.00001777864,0.00007473116,0.00009425272,0.00004042648],"domain_scores_gemma":[0.9998071,0.00003112988,0.00006535069,0.00003620712,0.00001561468,0.00004470854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002454255,0.000003813157,0.0001188944,0.000008919292,0.000001175914,0.00002335828,0.000007901233,0.00003179357,0.9989874,0.0002210579,0.00001922874,0.0005519131],"study_design_scores_gemma":[0.000008354944,0.00003216306,0.00321516,0.00000346409,0.000003803644,0.00009606971,0.00001508432,0.0004779674,0.9944749,0.00005488786,0.001615293,0.000002906574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739068,0.001347115,0.01843287,0.0002165593,0.00007182164,0.00002998963,0.0009153575,0.0003085676,0.004770846],"genre_scores_gemma":[0.9866011,0.0002794899,0.006067997,0.0001222578,0.00001264967,0.00002637873,0.0007875645,0.0002040827,0.005898482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001835935,"threshold_uncertainty_score":0.006141841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009095315086858848,"score_gpt":0.2244647084043134,"score_spread":0.2153693933174545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}