{"id":"W4399727957","doi":"10.1172/jci171136","title":"Triptolide and its prodrug Minnelide target high-risk MYC-amplified medulloblastoma in preclinical models","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Natural Compounds in Disease Treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Vince Lombardi Cancer Foundation; Hollings Cancer Center, Medical University of South Carolina; National Institutes of Health; Southeastern Brain Tumor Foundation; American Lebanese Syrian Associated Charities; Foundation for the National Institutes of Health; American Cancer Society; Alex's Lemonade Stand Foundation for Childhood Cancer; V Foundation for Cancer Research; College of Graduate Studies, Medical University of South Carolina; Rally Foundation; Southern Regional Education Board","keywords":"Triptolide; Medulloblastoma; Cancer research; In vivo; Medicine; Drug; Pharmacology; Toxicity; Oncology; Internal medicine; Biology; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003080392,0.0002235622,0.0008833248,0.0003709571,0.00004013974,0.00006695269,0.0001343956,0.0002869956,0.00004397097],"category_scores_gemma":[0.005073714,0.0001596016,0.0003287479,0.0004320622,0.0001735449,0.0005186501,0.00005724439,0.001383589,0.00001819304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001388125,"about_ca_system_score_gemma":0.0006116918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001536761,"about_ca_topic_score_gemma":0.000009319222,"domain_scores_codex":[0.9957449,0.0005029285,0.002505236,0.0003917388,0.0006217859,0.0002334283],"domain_scores_gemma":[0.9962493,0.001948466,0.0006729982,0.0002200022,0.0002680408,0.0006412616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.02719699,0.007076707,0.5635324,0.003636084,0.006149253,0.008817932,0.004492315,0.009063494,0.00713393,0.03823871,0.07486067,0.2498015],"study_design_scores_gemma":[0.01513522,0.005023652,0.3772804,0.00488785,0.002060004,0.0007726714,0.0001168942,0.1155964,0.005753846,0.4697958,0.002951725,0.0006255008],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813263,0.00582866,0.000229891,0.01094185,0.001126889,0.0003748942,0.00001444042,0.00004690672,0.0001102119],"genre_scores_gemma":[0.9864518,0.0008485552,0.01072058,0.0006687974,0.0009624858,0.0000108187,0.00001627645,0.00003059757,0.0002900868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4315571,"threshold_uncertainty_score":0.6508365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1074141762419219,"score_gpt":0.4114142899934565,"score_spread":0.3040001137515346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}