{"id":"W4399727957","doi":"10.1172/jci171136","title":"Triptolide and its prodrug Minnelide target high-risk MYC-amplified medulloblastoma in preclinical models","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Natural Compounds in Disease Treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Vince Lombardi Cancer Foundation; Hollings Cancer Center, Medical University of South Carolina; National Institutes of Health; Southeastern Brain Tumor Foundation; American Lebanese Syrian Associated Charities; Foundation for the National Institutes of Health; American Cancer Society; Alex's Lemonade Stand Foundation for Childhood Cancer; V Foundation for Cancer Research; College of Graduate Studies, Medical University of South Carolina; Rally Foundation; Southern Regional Education Board","keywords":"Triptolide; Medulloblastoma; Cancer research; In vivo; Medicine; Drug; Pharmacology; Toxicity; Oncology; Internal medicine; Biology; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001305408,0.0003188131,0.0003207618,0.000313458,0.000109489,0.0002533082,0.0002116953,0.0002632491,0.001450814],"category_scores_gemma":[0.00009688712,0.000128703,0.0002446929,0.0001461267,0.0001835476,0.0002437568,0.0001055415,0.0006960532,0.0002524733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004584892,"about_ca_system_score_gemma":0.0003158121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008201251,"about_ca_topic_score_gemma":0.002422918,"domain_scores_codex":[0.9999344,0.000008963775,0.000005746003,0.00001479893,0.00002006295,0.0000160322],"domain_scores_gemma":[0.9999497,0.000008297564,0.00001528884,0.00000514391,0.000006269921,0.00001528129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001191126,0.0003402639,0.0006730845,0.0001938571,0.00003045642,0.00009070022,0.00002327482,0.001087901,0.9861092,0.000253145,0.0003764739,0.009630491],"study_design_scores_gemma":[0.0002015985,0.006605738,0.004028379,0.0000184137,0.00006246575,0.0003217868,0.00003414028,0.002673049,0.9787549,0.0001568501,0.00713165,0.00001100993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898992,0.002120025,0.003238933,0.0001990298,0.0000432782,0.0001953009,0.001998178,0.000149029,0.002156984],"genre_scores_gemma":[0.9890103,0.002426502,0.004463257,0.00009479721,0.00001091446,0.0001486438,0.001892523,0.00002257828,0.001930453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001450814,"threshold_uncertainty_score":0.004853427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1074141762419219,"score_gpt":0.4114142899934565,"score_spread":0.3040001137515346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}