{"id":"W4399730570","doi":"10.21203/rs.3.rs-4457569/v1","title":"Interferon upregulation as the cause of Alzheimer’s disease","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; McGill University Health Centre","funders":"","keywords":"Downregulation and upregulation; Disease; Interferon; Alzheimer's disease; Medicine; Interferon γ; Immunology; Interferon gamma; Biology; Pathology; Cytokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004348738,0.0002635927,0.0003497779,0.0004798456,0.0001698918,0.0007281618,0.0001993074,0.0008071593,0.003427607],"category_scores_gemma":[0.0007748075,0.00008975711,0.0002200822,0.0003793979,0.0003359368,0.0003404671,0.0002675058,0.0004765186,0.000566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002678501,"about_ca_system_score_gemma":0.0001772798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003393126,"about_ca_topic_score_gemma":0.0002096093,"domain_scores_codex":[0.9998908,0.00003404637,0.000006966432,0.00002155115,0.00002850957,0.00001815282],"domain_scores_gemma":[0.9997963,0.00008714324,0.00004310852,0.00002727562,0.00002031507,0.00002580336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.01043844,0.0005326936,0.1086643,0.001760429,0.001075612,0.04645308,0.001157693,0.004511626,0.4049066,0.1408487,0.07247847,0.2071722],"study_design_scores_gemma":[0.0005934399,0.0005485282,0.2725967,0.0005973945,0.0009171356,0.05194468,0.001265651,0.02774252,0.1237348,0.4243234,0.09563211,0.0001036962],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8896857,0.03610777,0.01183883,0.01310673,0.002374582,0.00003263678,0.001728367,0.0004253724,0.04470007],"genre_scores_gemma":[0.981963,0.004761592,0.001791917,0.0003627483,0.0005976711,0.00001269407,0.0005020957,0.00005492219,0.009953303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003427607,"threshold_uncertainty_score":0.01146644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.149110725222452,"score_gpt":0.4274078032718489,"score_spread":0.2782970780493969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}