{"id":"W4399732387","doi":"10.1016/j.reprotox.2024.108645","title":"An in vitro testicular organoid model for the study of testis morphogenesis, somatic cell maturation, endocrine function, and toxicological assessment of endocrine disruptors","year":2024,"lang":"en","type":"article","venue":"Reproductive Toxicology","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Western College of Veterinary Medicine, University of Saskatchewan","keywords":"Organoid; Endocrine system; Somatic cell; Cell biology; Biology; Morphogenesis; Function (biology); Enteroendocrine cell; In vitro; Internal medicine; Endocrinology; Hormone; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004507585,0.0002019914,0.0004871115,0.000205825,0.00007102019,0.00001374357,0.00008079961,0.00006957811,0.00004441103],"category_scores_gemma":[0.001030472,0.0001346707,0.00006212647,0.0004331795,0.0001560145,0.0001038538,0.00005299494,0.000183405,7.730339e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001069541,"about_ca_system_score_gemma":0.0001792769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003372436,"about_ca_topic_score_gemma":0.0000180174,"domain_scores_codex":[0.9982084,0.0001397815,0.00053157,0.000674799,0.0002187266,0.0002267294],"domain_scores_gemma":[0.9982823,0.0007044193,0.0001350771,0.000525627,0.0002867974,0.00006585433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005189761,0.002950646,0.04266378,0.0003282267,0.0001532267,0.00003753017,0.0003761509,0.003899225,0.9472826,0.0004213229,0.00005363733,0.001314754],"study_design_scores_gemma":[0.002647242,0.007093817,0.6016649,0.00003800802,0.001087999,0.0003287731,0.001383881,0.2233254,0.160991,0.001211121,0.00003819317,0.0001896409],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802946,0.001002967,0.01523023,0.0006879158,0.000302417,0.002380364,0.00001803492,0.00005947234,0.00002402319],"genre_scores_gemma":[0.9953033,0.00003512835,0.003898391,0.00004502479,0.0001772435,0.0003929056,0.00003431906,0.0000284379,0.00008520795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7862915,"threshold_uncertainty_score":0.5491711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02312808159851676,"score_gpt":0.3173327270451688,"score_spread":0.2942046454466521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}