{"id":"W4399732387","doi":"10.1016/j.reprotox.2024.108645","title":"An in vitro testicular organoid model for the study of testis morphogenesis, somatic cell maturation, endocrine function, and toxicological assessment of endocrine disruptors","year":2024,"lang":"en","type":"article","venue":"Reproductive Toxicology","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Western College of Veterinary Medicine, University of Saskatchewan","keywords":"Organoid; Endocrine system; Somatic cell; Cell biology; Biology; Morphogenesis; Function (biology); Enteroendocrine cell; In vitro; Internal medicine; Endocrinology; Hormone; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008002094,0.0007336079,0.00058971,0.0006979071,0.0005413719,0.0005844518,0.0005992968,0.0006669018,0.001988194],"category_scores_gemma":[0.0002911632,0.0003252767,0.0009302394,0.0005106038,0.0004846097,0.0005677493,0.0006507334,0.001617799,0.0007493807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004910603,"about_ca_system_score_gemma":0.0007232477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001309442,"about_ca_topic_score_gemma":0.004105072,"domain_scores_codex":[0.999429,0.000128416,0.00006735481,0.0001522158,0.0001650973,0.00005787307],"domain_scores_gemma":[0.9994822,0.0001217971,0.00009951279,0.0001127488,0.00007711115,0.0001067048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003847892,0.00003712974,0.0004049391,0.0001999334,0.00001803034,0.0001817417,0.00006148819,0.0003473442,0.9963005,0.0003761619,0.0001312907,0.001902929],"study_design_scores_gemma":[0.00002396238,0.0009849475,0.004815905,0.00006187405,0.0001696301,0.001289004,0.00016785,0.003194226,0.964515,0.000290229,0.02444501,0.00004234997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5992275,0.02392709,0.350123,0.0007397859,0.001221234,0.001049204,0.00649504,0.001216491,0.01600058],"genre_scores_gemma":[0.8507666,0.01151277,0.1193791,0.0004580651,0.0001128295,0.001025084,0.006046232,0.0001679694,0.01053123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001988194,"threshold_uncertainty_score":0.006651223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02312808159851676,"score_gpt":0.3173327270451688,"score_spread":0.2942046454466521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}