{"id":"W4399733850","doi":"10.1101/2024.06.16.24309005","title":"A novel cortical biomarker signature predicts individual pain sensitivity","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Temporomandibular Joint Disorders","field":"Health Professions","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Parkwood Institute; Western University","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health","keywords":"Sensitivity (control systems); Biomarker; Signature (topology); Computer science; Psychology; Biology; Mathematics; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001120272,0.000451371,0.0004497499,0.0007809146,0.0001404153,0.0007568979,0.0002281124,0.0003491346,0.002018839],"category_scores_gemma":[0.005751141,0.0001447715,0.0003455156,0.0003753402,0.000257029,0.0003217223,0.0003740444,0.0003471313,0.0003923242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001347443,"about_ca_system_score_gemma":0.0002127137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009196571,"about_ca_topic_score_gemma":0.001206524,"domain_scores_codex":[0.9996345,0.0001097133,0.00003241592,0.00009884707,0.00007571094,0.00004887907],"domain_scores_gemma":[0.9979773,0.0009185812,0.0005355072,0.0001942162,0.0002690725,0.0001053682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001778613,0.0002040171,0.9046896,0.0001145313,0.0004627181,0.0002584673,0.0001194076,0.004295689,0.0388519,0.0001084295,0.0004764285,0.04864024],"study_design_scores_gemma":[0.00002675131,0.0005076553,0.9812362,0.00001979115,0.0001183499,0.0005129039,0.00007386055,0.0142158,0.002661514,0.0004157558,0.0001978536,0.00001358719],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945652,0.0002298483,0.004057936,0.00006235379,0.00001198796,0.00003528877,0.0004320993,0.00003761646,0.0005677152],"genre_scores_gemma":[0.9987676,0.00003860744,0.0008381811,0.00001573968,0.000007454873,0.00001272369,0.0001709774,0.000003411531,0.0001452749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002018839,"threshold_uncertainty_score":0.006753683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06776132369273867,"score_gpt":0.3729540138723758,"score_spread":0.3051926901796371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}