{"id":"W4399740668","doi":"10.1093/ofid/ofae257","title":"Meeting the Therapeutic Challenges of Emergent and Rare Invasive Fungal Diseases Through Novel Clinical Trial Designs","year":2024,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Sick Kids Foundation; Omeros Corporation; Gilead Sciences; Astellas Pharma; Abbott Laboratories","keywords":"Medicine; Clinical trial; Intensive care medicine; Clinical study design; Aspergillosis; Mucormycosis; Randomized controlled trial; Rare disease; Antifungal; Disease; Medical physics; Pathology; Immunology; Dermatology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004130015,0.000233255,0.0005502124,0.00004160752,0.0002612295,0.000128152,0.0002175778,0.00009532148,0.0001715083],"category_scores_gemma":[0.0009583135,0.0001452093,0.0003612429,0.0001807468,0.0003743636,0.0002933828,0.0002611862,0.000213718,0.00001311173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004499391,"about_ca_system_score_gemma":0.000490227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001167949,"about_ca_topic_score_gemma":0.000356679,"domain_scores_codex":[0.998055,0.0002176583,0.0005748749,0.0005318976,0.0003122163,0.0003083443],"domain_scores_gemma":[0.9978944,0.001197048,0.0001332682,0.0004651256,0.0001226824,0.0001874912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02142243,0.004516031,0.8816047,0.001507353,0.001846952,0.0001097122,0.0009564774,0.0000103138,0.0004316639,0.03421431,0.005446309,0.04793371],"study_design_scores_gemma":[0.03528471,0.007152345,0.9110792,0.002259752,0.00404682,0.00006895507,0.007915962,0.0002555316,0.0004353468,0.02025966,0.01044293,0.0007987918],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8821734,0.09767765,0.0003277776,0.005004023,0.001103414,0.00362811,0.0002872732,0.0001728161,0.009625604],"genre_scores_gemma":[0.9896733,0.009062646,0.00002658157,0.0005991352,0.0002654344,0.0001378146,0.00002100115,0.00003419639,0.0001799593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1074999,"threshold_uncertainty_score":0.5921464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1374145785578214,"score_gpt":0.4035730070726949,"score_spread":0.2661584285148736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}