{"id":"W4399740688","doi":"10.1038/s41582-024-00973-9","title":"From spreading depolarization to blood–brain barrier dysfunction: navigating traumatic brain injury for novel diagnosis and therapy","year":2024,"lang":"en","type":"review","venue":"Nature Reviews Neurology","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University","funders":"","keywords":"Traumatic brain injury; Neuroinflammation; Medicine; Blood–brain barrier; Pathological; Neuroscience; Intensive care medicine; Depolarization; Bioinformatics; Inflammation; Psychology; Pathology; Internal medicine; Central nervous system; Psychiatry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0005385097,0.0006211159,0.001441714,0.0001079093,0.0001277709,0.00008873594,0.0003036323,0.001534215,0.0000207175],"category_scores_gemma":[0.001024597,0.0004700813,0.0005645744,0.0003043568,0.00004729631,0.000008048514,0.0001618576,0.001120002,0.0000130169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009789911,"about_ca_system_score_gemma":0.0000911546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001363905,"about_ca_topic_score_gemma":0.00001993372,"domain_scores_codex":[0.9972561,0.0003423132,0.0007799464,0.001151078,0.0001109698,0.0003596029],"domain_scores_gemma":[0.9986498,0.0002696,0.0003489371,0.0005281856,0.00005414843,0.000149353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000247058,0.00004232691,0.000009284444,0.004136945,0.0001979501,0.000004236506,0.00003493771,2.121345e-7,0.003829341,0.00004710819,0.00768973,0.9839832],"study_design_scores_gemma":[0.0002529623,0.000756646,0.000002735558,0.003922289,0.0005620935,0.00006132808,0.000002092652,0.000006222514,0.0003461352,0.00005740192,0.9936194,0.0004106739],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009048376,0.9925067,0.000865666,0.001150455,0.0007890638,0.003278514,0.0004574289,0.00003070507,0.00001658374],"genre_scores_gemma":[0.00007080298,0.9860165,0.00118937,0.007720484,0.001840015,0.001969698,0.0009588876,0.00013795,0.00009632826],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9859297,"threshold_uncertainty_score":0.9997751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03936867677449828,"score_gpt":0.3647992353038864,"score_spread":0.3254305585293881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}