{"id":"W4399749722","doi":"10.3390/cells13121041","title":"Lysosome-Disrupting Agents in Combination with Venetoclax Increase Apoptotic Response in Primary Chronic Lymphocytic Leukemia (CLL) Cells Mediated by Lysosomal Cathepsin D Release and Inhibition of Autophagy","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba; Alberta Health Services; University of Alberta","funders":"National Institute of Environmental Health Sciences","keywords":"Venetoclax; Obinutuzumab; Chronic lymphocytic leukemia; Autophagy; Cancer research; Cathepsin B; Programmed cell death; Cathepsin; Lysosome; Ibrutinib; Vorinostat; Apoptosis; Carfilzomib; Leukemia; Biology; Pharmacology; Chemistry; Immunology; Bortezomib; Multiple myeloma; Biochemistry; Histone deacetylase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001073941,0.0003030673,0.0003542941,0.0002207911,0.0001390219,0.0001824275,0.00009959925,0.0001747128,0.001100146],"category_scores_gemma":[0.00008818015,0.00008906454,0.0002293982,0.0002204869,0.0001388101,0.0001685605,0.0001382261,0.000487429,0.0001570398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001883532,"about_ca_system_score_gemma":0.0001852148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006102691,"about_ca_topic_score_gemma":0.001546478,"domain_scores_codex":[0.999902,0.00002152062,0.00001266656,0.00001677022,0.0000185184,0.00002861828],"domain_scores_gemma":[0.9999387,0.00001710217,0.00001382068,0.000007259526,0.000006254815,0.00001689696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006094212,0.0001471653,0.0002844862,0.00008986772,0.00001102402,0.00005560694,0.0000365451,0.0001006516,0.9952947,0.00003057499,0.0001150499,0.003224947],"study_design_scores_gemma":[0.0001101837,0.003631394,0.008706744,0.000008539777,0.00004128595,0.0002918009,0.0000346437,0.0005837117,0.9839978,0.00001799785,0.002569079,0.000006812531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957274,0.002540359,0.0003854868,0.00005513058,0.00003747576,0.00003704989,0.0002143622,0.00006973647,0.0009330324],"genre_scores_gemma":[0.995758,0.001515515,0.001031033,0.00003898269,0.00002408137,0.00004864065,0.0003522627,0.000007290523,0.001224239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001100146,"threshold_uncertainty_score":0.003680348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01117693434174544,"score_gpt":0.263320768523523,"score_spread":0.2521438341817775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}