{"id":"W4399749722","doi":"10.3390/cells13121041","title":"Lysosome-Disrupting Agents in Combination with Venetoclax Increase Apoptotic Response in Primary Chronic Lymphocytic Leukemia (CLL) Cells Mediated by Lysosomal Cathepsin D Release and Inhibition of Autophagy","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba; Alberta Health Services; University of Alberta","funders":"National Institute of Environmental Health Sciences","keywords":"Venetoclax; Obinutuzumab; Chronic lymphocytic leukemia; Autophagy; Cancer research; Cathepsin B; Programmed cell death; Cathepsin; Lysosome; Ibrutinib; Vorinostat; Apoptosis; Carfilzomib; Leukemia; Biology; Pharmacology; Chemistry; Immunology; Bortezomib; Multiple myeloma; Biochemistry; Histone deacetylase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001192717,0.0003394241,0.000605156,0.0008172811,0.0000463079,0.00005305124,0.0001296593,0.0002698178,0.00008250159],"category_scores_gemma":[0.0002401642,0.0003149883,0.00007025102,0.001225029,0.0003039771,0.0002458511,0.0001347396,0.0004510868,0.0000664553],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.1146032,"about_ca_system_score_gemma":0.02981269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002809507,"about_ca_topic_score_gemma":0.00008110868,"domain_scores_codex":[0.9967529,0.0004242487,0.0007562562,0.0006982184,0.0007289751,0.0006394439],"domain_scores_gemma":[0.9981386,0.0009279146,0.0001174848,0.0004326144,0.00008897603,0.000294401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006326615,0.0002084258,0.000247029,0.003873669,0.00007440858,0.003376912,0.001385907,0.002594809,0.9795147,0.0000198269,0.0006171164,0.00176065],"study_design_scores_gemma":[0.03868653,0.001586754,0.004410126,0.003959174,0.0001307843,0.0002447663,0.0001785964,0.4067716,0.5432815,0.00004210978,0.0002655205,0.0004425541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956613,0.002571758,0.00002834285,0.00006009702,0.0001087019,0.001162955,0.00004154983,0.00009392316,0.0002713749],"genre_scores_gemma":[0.9983402,0.0004295012,0.0001268228,0.0001022709,0.00004733406,0.00007510356,0.0002176426,0.00008736767,0.0005737531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4362332,"threshold_uncertainty_score":0.9999302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01117693434174544,"score_gpt":0.263320768523523,"score_spread":0.2521438341817775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}