{"id":"W4399752222","doi":"10.1242/dmm.050528","title":"An <i>Irak1-Mecp2</i> tandem duplication mouse model for the study of <i>MECP2</i> duplication syndrome","year":2024,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Ontario Ministry of Health and Long-Term Care; Canadian Child Health Clinician Scientist Program","keywords":"MECP2; Gene duplication; Tandem exon duplication; Biology; CRISPR; Copy-number variation; Rett syndrome; Genetics; Gene; Cancer research; Genome; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004176465,0.001069702,0.0005575402,0.001626934,0.0005601878,0.000518936,0.0008300921,0.001489518,0.005083026],"category_scores_gemma":[0.0002007799,0.0004211851,0.0006072758,0.0005162347,0.0007440768,0.0005868901,0.0005951191,0.001991584,0.001542522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005390096,"about_ca_system_score_gemma":0.0005193373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007899947,"about_ca_topic_score_gemma":0.001747098,"domain_scores_codex":[0.9995035,0.00007225937,0.0000661899,0.0001456364,0.0001305848,0.00008171809],"domain_scores_gemma":[0.999586,0.00005383025,0.0001300147,0.00004437636,0.00003749462,0.0001482168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000196823,0.0001163436,0.0002865616,0.00007095312,0.00001740467,0.0004041891,0.00005710739,0.0001522518,0.9945841,0.001086869,0.0003979652,0.002629379],"study_design_scores_gemma":[0.0001827889,0.00105476,0.005052662,0.00008248492,0.0001142763,0.00490624,0.0001481754,0.003292848,0.9540848,0.0006293734,0.0304121,0.00003953441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9128917,0.002749311,0.05950482,0.00137651,0.0005721783,0.0005708489,0.009427617,0.002027157,0.01087975],"genre_scores_gemma":[0.8753153,0.003199152,0.07067215,0.000614859,0.00009913948,0.001411828,0.007781885,0.0005568563,0.04034879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005083026,"threshold_uncertainty_score":0.01700443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907596196004142,"score_gpt":0.259768009737227,"score_spread":0.2406920477771856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}