{"id":"W4399754427","doi":"10.1111/iej.14106","title":"Mitochondrial biogenesis disorder and oxidative damage promote refractory apical periodontitis in rat and human","year":2024,"lang":"en","type":"article","venue":"International Endodontic Journal","topic":"Endodontics and Root Canal Treatments","field":"Dentistry","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Wenzhou Municipal Science and Technology Bureau","keywords":"Oxidative stress; Mitochondrial biogenesis; Mitochondrion; Biology; Molecular biology; Malondialdehyde; Periodontitis; Pathology; Andrology; Cell biology; Internal medicine; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004338707,0.0003608,0.0004414242,0.0007562487,0.0002866367,0.0003160305,0.0001309901,0.000513007,0.00233715],"category_scores_gemma":[0.0003210093,0.0002581029,0.0003366746,0.0003112197,0.0003113882,0.0002370587,0.0003104773,0.000468715,0.0005282988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001155999,"about_ca_system_score_gemma":0.0002163662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003488697,"about_ca_topic_score_gemma":0.0004325047,"domain_scores_codex":[0.99983,0.00003066421,0.00001536906,0.00004139726,0.00004176043,0.00004082497],"domain_scores_gemma":[0.9998032,0.00002033673,0.00008640559,0.00003047564,0.00001803755,0.00004156704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01553822,0.002309838,0.08404075,0.0007403613,0.0001548306,0.01343759,0.0008353611,0.0001595371,0.8301992,0.0005420335,0.001039865,0.05100248],"study_design_scores_gemma":[0.0004988645,0.02152741,0.8221714,0.0002006448,0.0003986832,0.06293728,0.001720215,0.001141699,0.07651874,0.0005326217,0.01228487,0.00006763286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941876,0.004054629,0.0006654885,0.00007809243,0.00001859076,0.00005245559,0.0001445085,0.00004187863,0.0007568798],"genre_scores_gemma":[0.9966146,0.001885487,0.0004291103,0.00006299941,0.00002213929,0.00004158777,0.0001869904,0.000004316781,0.0007527222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00233715,"threshold_uncertainty_score":0.00781858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01347428589678345,"score_gpt":0.297852036180442,"score_spread":0.2843777502836586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}