{"id":"W4399760161","doi":"10.1210/clinem/dgae411","title":"Double CYP11B1/CYP11B2 Immunohistochemistry and Detection of KCNJ5 Mutations in Primary Aldosteronism","year":2024,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Department of Medicine, Ottawa Hospital; Foundation for Advanced Research; Research Foundation for Advanced Talents of Ludong University; Università degli Studi di Padova","keywords":"Aldosterone synthase; Sanger sequencing; Steroid 11-beta-hydroxylase; Primary aldosteronism; Immunohistochemistry; Biology; Hyperaldosteronism; Adenoma; Aldosterone; Mutation; Genetics; Endocrinology; Renin–angiotensin system; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009779626,0.0001074661,0.0006489755,0.0001782372,0.0000398501,0.000008011119,0.00009934027,0.0001270832,0.00003199504],"category_scores_gemma":[0.000264919,0.00006717815,0.0001908025,0.000162938,0.000334926,0.00009948123,0.00004756869,0.0007893083,0.000006700328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002756312,"about_ca_system_score_gemma":0.000224934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002725487,"about_ca_topic_score_gemma":0.000003725951,"domain_scores_codex":[0.9981517,0.0001569252,0.001176614,0.0001195574,0.0002332053,0.000161963],"domain_scores_gemma":[0.9986781,0.0005830018,0.0002935932,0.0001770766,0.000180561,0.00008769653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004391307,0.0003639783,0.001891381,0.0001630826,0.0005210861,0.0004050786,0.000611723,0.00003827225,0.7337642,0.00154048,0.0002392445,0.2560702],"study_design_scores_gemma":[0.01317447,0.0008616283,0.841602,0.0004443924,0.001844517,0.0086346,0.0004429182,0.000723712,0.06150922,0.002784736,0.06776353,0.0002143113],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9679783,0.02590085,0.0001964768,0.004609945,0.000544903,0.0001221143,0.000001309663,0.00001237747,0.0006336975],"genre_scores_gemma":[0.9943226,0.004357868,0.0002569059,0.0003598416,0.0003296018,0.00000198491,0.000001980606,0.00001266708,0.0003565807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8397106,"threshold_uncertainty_score":0.3429196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04543775626482884,"score_gpt":0.3876250863296337,"score_spread":0.3421873300648049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}