{"id":"W4399760686","doi":"10.1093/neuonc/noae064.129","title":"DIPG-76. PEDIATRIC PATIENTS WITH DIFFUSE MIDLINE GLIOMA DEMONSTRATE AN UNEXPECTED PREVALENCE OF GERMLINE VARIANTS IN HOMOLOGOUS RECOMBINATION GENES","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; McGill University Health Centre","funders":"","keywords":"Germline; Homologous recombination; Recombination; Gene; Genetics; Homologous chromosome; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001467874,0.0003461353,0.0002498133,0.0007275219,0.0003823748,0.0005198301,0.0002684608,0.0003556321,0.002358538],"category_scores_gemma":[0.0007384314,0.0002107661,0.0001796701,0.0007996716,0.0002888446,0.0002522466,0.0003940007,0.0003047237,0.0004088567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002000757,"about_ca_system_score_gemma":0.0002044223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001463844,"about_ca_topic_score_gemma":0.001741581,"domain_scores_codex":[0.9997323,0.00002279989,0.00002124219,0.0001237384,0.00005151228,0.00004837654],"domain_scores_gemma":[0.9996796,0.00005043697,0.0001336525,0.0000290163,0.00002064271,0.0000866488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001959853,0.00002310332,0.9758825,0.00003273391,0.0000340359,0.007734803,0.0001608892,0.0001103217,0.009214535,0.0001334776,0.000329297,0.006148234],"study_design_scores_gemma":[0.00001155179,0.0001174831,0.958114,0.00001224713,0.00003407487,0.03836607,0.0002217186,0.0002906001,0.001586985,0.0001154498,0.001123542,0.000006343598],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987713,0.0001524708,0.0001246262,0.00002322955,0.000002635211,0.000007916704,0.0002981586,0.00001148769,0.0006082091],"genre_scores_gemma":[0.9991424,0.00009025077,0.000173946,0.0000189489,0.000004790278,0.000005230554,0.0004473017,0.000005432415,0.0001117202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002358538,"threshold_uncertainty_score":0.007890046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01392210584393889,"score_gpt":0.2785072447483076,"score_spread":0.2645851389043687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}